31 documents found, page 1 of 4
Predictors of gaming disorder in children and adolescents: a school-based study
Ferreira,Felipe de M.; Bambini,Beatriz B.; Tonsig,Gabriela K.; Fonseca,Lais; Picon,Felipe A.; Pan,Pedro M.; Salum,Giovanni A.; Jackowski,AndreaObjective: To determine whether psychiatric and gaming pattern variables are associated with gaming disorder in a school-based sample. Methods: We analyzed data from the Brazilian High-Risk Cohort for Psychiatric Disorders, a community sample aged 10 to 18, using questionnaires on gaming use patterns. We applied the Gaming Addiction Scale to diagnose gaming disorder and the Development and Well-Being Behavior A...
Cannabidiol for the treatment of crack-cocaine craving: an exploratory double-b...
Meneses-Gaya,Carolina de; Crippa,José A.; Hallak,Jaime E.; Miguel,André Q.; Laranjeira,Ronaldo; Bressan,Rodrigo A.; Zuardi,Antonio W.; Lacerda,Acioly L.Objective: To assess the efficacy of cannabidiol (CBD) in the management of crack-cocaine craving and the treatment of frequent withdrawal symptoms. Methods: Thirty-one men with a diagnosis of crack-cocaine dependence were enrolled in a randomized, double-blind, placebo-controlled trial. We applied neuropsychological tests and assessed craving intensity, anxiety and depression symptoms, and substance use patter...
Diversity matters: opportunities in the study of the genetics of psychotic diso...
Fonseca,Lais; Sena,Brena F.; Crossley,Nicolas; Lopez-Jaramillo,Carlos; Koenen,Karestan; Freimer,Nelson B.; Bressan,Rodrigo A.; Belangero,Sintia I.Lack of diversity regarding genetic and environmental backgrounds weakens the generalization and clinical applicability of research findings on psychotic disorders. Notably, Latin Americans have been generally neglected in genetic studies, comprising less than 2% of genome-wide association study samples. But Latin American populations represent a unique opportunity for research, given the exceptionally high eth...
Schneider’s first-rank symptoms as predictors of remission in antipsychotic-nai...
Malinowski,Fernando R.; Tasso,Brazilio de C.; Ortiz,Bruno B.; Higuchi,Cinthia H.; Noto,Cristiano; Belangero,Sintia I.; Bressan,Rodrigo A.; Gadelha,AryObjective: German psychiatrist Kurt Schneider proposed the concept of first-rank symptoms (FRS) of schizophrenia in 1959. However, their relevance for diagnosis and prediction of treatment response are still unclear. Most studies have investigated FRS in chronic or medicated patients. The present study sought to evaluate whether FRS predict remission, response, or improvement in functionality in antipsychotic-n...
Population neuroscience: challenges and opportunities for psychiatric research ...
Cirillo,Alessandra; Diniz,Elton; Gadelha,Ary; Asevedo,Elson; Axelrud,Luiza K.; Miguel,Eurípedes C.; Rohde,Luis Augusto; Bressan,Rodrigo A.; Pan,PedroObjective: Population neuroscience is an emerging field that combines epidemiology and neuroscience to study how genes and the environment shape typical and atypical brain functioning. The objective of this study was to review key studies on population neuroscience from low- and middle-income countries (LMICs) and to identify potential gaps vis-à-vis studies conducted in high-income countries. Methods: We condu...
Lowering costs for large-scale screening in psychosis: a systematic review and ...
Argolo,Felipe; Magnavita,Guilherme; Mota,Natalia Bezerra; Ziebold,Carolina; Mabunda,Dirceu; Pan,Pedro M.; Zugman,André; Gadelha,Ary; Corcoran,CherylObjective: Obstacles for computational tools in psychiatry include gathering robust evidence and keeping implementation costs reasonable. We report a systematic review of automated speech evaluation for the psychosis spectrum and analyze the value of information for a screening program in a healthcare system with a limited number of psychiatrists (Maputo, Mozambique). Methods: Original studies on speech analysi...
Component mechanisms of executive function in schizophrenia and their contribut...
Berberian,Arthur A.; Gadelha,Ary; Dias,Natália M.; Mecca,Tatiana P.; Comfort,William E.; Bressan,Rodrigo A.; Lacerda,Acioly T.Objective: In schizophrenia, scores reflecting deficits in different cognitive processes are strongly correlated, making it difficult to establish a solid relationship between different cognitive mechanisms and other features of this disorder. The objective of this study was to explore whether three frequently postulated executive functions (updating, shifting, and inhibition) could be compared between groups a...
Schizophrenia and work: aspects related to job acquisition in a follow-up study
Martini,Larissa C.; Barbosa Neto,Jair B.; Petreche,Beatriz; Fonseca,Ana O.; Santos,Fernanda V. dos; Magalhães,Lílian; Marques,Alessandra G.Objective: Work is considered one of the main forms of social organization; however, few individuals with schizophrenia find work opportunities. The purpose of this study was to evaluate the relationship between schizophrenia symptoms and job acquisition. Method: Fifty-three individuals diagnosed with schizophrenia from an outpatient treatment facility were included in an 18-month follow-up study. After enrollm...
The role of the CNR1 gene in schizophrenia: a systematic review including unpub...
Gouvêa,Eduardo S.; Santos Filho,Airton F.; Ota,Vanessa K.; Mrad,Vinicius; Gadelha,Ary; Bressan,Rodrigo A.; Cordeiro,Quirino; Belangero,Sintia I.Objective: Schizophrenia is a multifactorial disorder. It is known that a combination of extensive multiple common alleles may be involved in its etiology, each contributing with a small to moderate effect, and, possibly, some rare alleles with a much larger effect size. We aimed to perform a systematic review of association studies between schizophrenia (and its subphenotypes) and polymorphisms in the CNR1 gen...
Catechol-O-methyltransferase (COMT) polymorphisms modulate working memory in in...
Matsuzaka,Camila T.; Christofolini,Denise; Ota,Vanessa K.; Gadelha,Ary; Berberian,Arthur A.; Noto,Cristiano; Mazzotti,Diego R.; Spindola,Leticia M.Objective: Cognitive impairment is a core feature of schizophrenia, related to dopaminergic dysfunction in the prefrontal cortex (PFC). It is hypothesized that functional single nucleotide polymorphism (SNP) rs4680 of the catechol-O-methyltransferase (COMT) gene could mediate the relationship between cognition and dopamine activity in the PFC. Other COMT SNPs could also play a role. Methods: We evaluated the ro...