56 documents found, page 1 of 6
PO 111 - Síndrome QT longo, silencioso e potencialmente fatal - case report
Santos, Olga; Rosinha, Daniela; Gonçalves, Nádia; Maia, Paulox
Professional Quality of Life Among Physicians and Nurses Working in Portuguese ...
Serrão, Carla; Martins, Vera; Ribeiro, Carla; Maia, Paulo; Pinho, Rita; Teixeira, Andreia; Castro, Luísa; Duarte, IvoneBackground: In the last 2 weeks of January 2021, Portugal was the worst country in the world in incidence of infections and deaths due to COVID-19. As a result, the pressure on the healthcare system increased exponentially, exceeding its capacities and leaving hospitals in near collapse. This scenario caused multiple constraints, particularly for hospital medical staff. Previous studies conducted at different m...
Retrospective study of the concordance between clinical and histopathological d...
Ramos, Andreia; Borrecho, Gonçalo; Zagalo, Luísa; Proença, Luís; Maia, Paulo; Gomes, João; Marques, JoséObjectives: Evaluate the agreement between the clinical and histopathological diagnosis of oral lesions in patients submitted to biopsies. Identify the most frequent oral lesions and their correlation with age, gender, and anatomical location. Methods: A retrospective study of 368 pathological examinations collected between 2008 and 2018, corresponding to biopsies performed at the Clínica Universitária Egas Mon...
Model-guided development of an evolutionarily stable yeast chassis
Pereira, Filipa; Lopes, Hélder; Maia, Paulo; Meyer, Britta; Nocon, Justyna; Jouhten, Paula; Konstantinidis, Dimitrios; Kafkia, Eleni; Rocha, MiguelAbstract First-principle metabolic modelling holds potential for designing microbial chassis that are resilient against phenotype reversal due to adaptive mutations. Yet, the theory of model-based chassis design has rarely been put to rigorous experimental test. Here, we report the development of Saccharomyces cerevisiae chassis strains for dicarboxylic acid production using genome-scale metabolic modelling. Th...
Necrotizing sialometaplasia and bulimia: a case report
Salvado, Francisco; Nobre, Miguel de Araújo; Gomes, João; Maia, PauloBulimia is an eating disorder with a great prevalence in young women. Due to its multifactor ethiology, bulimia has systemic consequences. In the literature, necrotising sialometaplasia is seldom associated with bulimia. Its etiopathogenesis is discussed by several authors; nevertheless, the consensus does not consider the relevance of local trauma associated with induced vomiting. A case of necrotising sialome...
Necrotizing sialometaplasia and bulimia: a case report
Salvado, Francisco; Nobre, Miguel de Araújo; Gomes, João; Maia, PauloBulimia is an eating disorder with a great prevalence in young women. Due to its multifactor ethiology, bulimia has systemic consequences. In the literature, necrotising sialometaplasia is seldom associated with bulimia. Its etiopathogenesis is discussed by several authors; nevertheless, the consensus does not consider the relevance of local trauma associated with induced vomiting. A case of necrotising sialome...
MEMOTE for standardized genome-scale metabolic model testing
Lieven, Christian; Beber, Moritz E.; Olivier, Brett G.; Bergmann, Frank T.; Ataman, Meric; Babaei, Parizad; Bartell, Jennifer A.; Blank, Lars M.Reconstructing metabolic reaction networks enables the development of testable hypotheses of an organisms metabolism under different conditions1. State-of-the-art genome-scale metabolic models (GEMs) can include thousands of metabolites and reactions that are assigned to subcellular locations. Geneproteinreaction (GPR) rules and annotations using database information can add meta-information to GEMs. GEMs with ...
Publisher Correction: MEMOTE for standardized genome-scale metabolic model testing
Lieven, Christian; Beber, Moritz E.; Olivier, Brett G.; Bergmann, Frank T.; Ataman, Meric; Babaei, Parizad; Bartell, Jennifer A.; Blank, Lars M.An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Changes in End-of-Life Practices in European Intensive Care Units From 1999 to ...
Sprung, Charles L; Ricou, Bara; Hartog, Christiane S; Maia, Paulo; Mentzelopoulos, Spyros D; Weiss, Manfred; Levin, Phillip D; Galarza, LauraImportance: End-of-life decisions occur daily in intensive care units (ICUs) around the world, and these practices could change over time. Objective: To determine the changes in end-of-life practices in European ICUs after 16 years. Design, setting, and participants: Ethicus-2 was a prospective observational study of 22 European ICUs previously included in the Ethicus-1 study (1999-2000). During a self-selected...
Turnover dependent phenotypic simulation: a quantitative constraint-based simul...
Pereira, Rui Miguel Pinheiro Silva; Vilaça, P.; Maia, Paulo; Nielsen, Jens; Rocha, I.The uncertain relationship between genotype and phenotype can make strain engineering an arduous trial and error process. To identify promising gene targets faster, constraint-based modelling methodologies are often used, although they remain limited in their predictive power. Even though the search for gene knock-outs is fairly established in constraint-based modelling, most strain design methods still model g...