39 documents found, page 1 of 4

Optimizing Hospital Referrals: From Overload to Solution

Optimizing Hospital Referrals: From Overload to Solution

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COMO PODE O DESENHO URBANO PROMOVER A LIGAÇÃO À NATUREZA?

Este estudo revê o conhecimento atual sobre o papel que o desenho urbano desempenha na promoção da conexão com a natureza e discute o valor da figitalização para a reconexão da população urbana com a natureza. A promoção da conexão com a natureza na cidade é importante, dado que a maioria da população humana vive em cidades, e as pessoas que se sentem mais conectadas à natureza tendem a retirar dela mais benefí...

Eltrombopag Use in Children with Persistent and Chronic Primary Immune Thromboc...

Eltrombopag Use in Children with Persistent and Chronic Primary Immune Thromboc...

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A Mother's Deficiency, a Baby's Challenge: Vitamin B12 Deficiency Related Seizu...

Anemia is prevalent in pediatric age and it stems from diverse factors. While iron deficiency is a common cause above six months of age, other nutritional deficits contribute to the disease burden. During pregnancy, anemia due to nutritional deficits is associated with adverse outcomes for the newborn. Precise diagnosis of dietary deficits in the pediatric population is vital to avert negative health consequenc...

Biomarkers and genetic modulators of cerebral vasculopathy in sub-Saharan ances...

We investigated biomarkers and genetic modulators of the cerebral vasculopathy (CV) subphenotype in pediatric sickle cell anemia (SCA) patients of sub-Saharan African ancestry. We found that one VCAM1 promoter haplotype (haplotype 7) and VCAM1 single nucleotide variant rs1409419_T were associated with stroke events, stroke risk, as measured by time-averaged mean of maximum velocity in the middle cerebral artery...

Moduladores genéticos de vasculopatia cerebral em crianças com drepanocitose

A drepanocitose é uma doença genética causada pela mutação c.20A>T, em homozigotia, no gene da beta-globina, que leva à síntese de uma hemoglobina anómala – hemoglobina S. Para além da anemia hemolítica crónica, as manifestações clínicas são diversas e, em crianças, a mais grave é a vasculopatia cerebral que inclui os acidentes vasculares cerebrais (AVC) e os enfartes cerebrais silenciosos. Apesar de monogénica...

Biomarkers and genetic modulators of cerebral vasculopathy in sub-Saharan ances...

We investigated biomarkers and genetic modulators of the cerebral vasculopathy (CV) subphenotype in pediatric sickle cell anemia (SCA) patients of sub-Saharan African ancestry. We found that one VCAM1 promoter haplotype (haplotype 7) and VCAM1 single nucleotide variant rs1409419_T were associated with stroke events, stroke risk, as measured by time-averaged mean of maximum velocity in the middle cerebral artery...

The protein Matriptase-2 damaged by a novel missense mutation in the TMPRSS6 ge...

Iron-refractory iron deficiency anemia (IRIDA) is a rare autosomal recessive anemia usually unresponsive to oral iron intake and partially responsive to parenteral iron treatment. This disease is the result of mutations in TMPRSS6 gene, encoding Matriptase-2, a transmembrane serine protease that plays a key role in down-regulating hepcidin, allowing iron bioavailability for erythropoiesis. Once TMPRSS6 is mutat...