4 documents found, page 1 of 1
PDMS porous microneedles used as engineered tool in advanced microfluidic devic...
Maia, Renata Patrícia Faria; Sousa, Paulo Jorge Teixeira; Pinto, Vânia Cristina Gonçalves; Soares, Delfim; Lima, Rui Alberto Madeira MacedoThe advancement of organ-on-a-chip (OoC), as end-use preclinical tool, has been slackened with the techno logical and engineering challenges that in-situ real-time monitoring of physicochemical and biological param eters still represent. In this study, the envisioned solution to surpass this challenge is the integration of a microneedle (MN) patch into a microfluidic device to collect cell culture media directl...
Microneedles in advanced microfluidic systems: a systematic review throughout l...
Maia, Renata Patrícia Faria; Carvalho, Violeta Meneses; Lima, Rui; Minas, Graça; Rodrigues, Raquel OliveiraMicroneedles (MNs) have been widely used in biomedical applications for drug delivery and biomarker detection purposes. Furthermore, MNs can also be used as a stand-alone tool to be combined with microfluidic devices. For that purpose, lab- or organ-on-a-chip are being developed. This systematic review aims to summarize the most recent progress in these emerging systems, to identify their advantages and limitat...
Development and characterization of porous PDMS microneedles
Maia, Renata Patrícia Faria; Sousa, Paulo Jorge Teixeira; Pinto, Vânia Cristina Gonçalves; Lima, Rui Alberto Madeira Macedo; Minas, GraçaThis study aimed the development and characterization of polydimethylsiloxane (PDMS) porous microneedles (MNs) cast with silica nanoparticles as porogenic material for biomedical applications. To produce the porous PDMS MNs, different concentrations of silica nanoparticles were cast into PDMS, followed by chemical etching to remove the casted material and produce a porogenic network. This chemical etching was a...
Diagnosis methods for COVID-19: A systematic review
Maia, Renata Patrícia Faria; Carvalho, Violeta Meneses; Faria, Bernardo Almeida Leite; Miranda, Inês Sofia Ferreira; Catarino, Susana OliveiraAt the end of 2019, the coronavirus appeared and spread extremely rapidly, causing millions of infections and deaths worldwide, and becoming a global pandemic. For this reason, it became urgent and essential to find adequate tests for an accurate and fast diagnosis of this disease. In the present study, a systematic review was performed in order to provide an overview of the COVID-19 diagnosis methods and tests...