Fluoorganic compounds are ubiquitous environmental pollutants due to their widespread use and high environmental persistence, mostly attributed to the stability of their carbon-fluoride bonds. The biotransformation of these compounds has been observed in some microorganisms, but defluorination (cleavage of carbon-fluorine bonds) remains the limiting step. Intracellular accumulation of fluoride occurs during mic...
Among the many pollutants that afflict aquatic ecosystems, PFAS (per- and polyfluoroalkyl substances) stand out due to their distribution, environmental persistence and ecotoxicity. Currently, there are no suitable remediation technologies capable of mitigating PFAS-related pollution in these ecosystems. Yet, the combination of nanophotocatalysis (NPC) and bioremediation (BRMD) may prove useful in combating PFA...
Assessing public and patients’ expectations and concerns about genomic data sharing is essential to promote adequate data governance and engagement in rare diseases genomics research. This cross-sectional study compared the views of 159 rare disease patients, 478 informal carers and 63 healthcare professionals in Northern Portugal about the benefits and risks of sharing genomic data for research, and its associ...
Este trabalho de projeto, tem como principal objetivo a criação de um plano de Marketing para a marca Detours que atua no setor dos serviços, no ramo do turismo. No presente projeto são abordados múltiplos aspetos inerentes ao conceito de Marketing. Após enquadramento teórico dos conceitos subjacentemente associados – nomeadamente, Plano de Marketing, Marketing de Serviços e Marketing de Turismo – procedeu-se a...
Background: During exposure therapy, patients report increases in fear that generally decrease within and across exposure sessions. Our main aim was to characterize these changes in fear ratings mathematically; a secondary aim was to test whether the resulting model would help to predict treatment outcome. Methods: We applied tools of computational psychiatry to a previously published dataset in which 30 women ...
Public involvement in the governance of epidemiological and public health studies can foster needs-driven research, enhance participants' recruitment, reduce attrition and improve the quality of and ethics in research and surveillance. However, it can also reinforce health inequalities if it fails to ensure public representation across socioeconomic gradients. This study aimed to assess patients' and carers' pr...
A Frente Atlântica do Porto é uma associação intermunicipal de fins múltiplos constituída pelos municípios de Matosinhos, Porto e Vila Nova de Gaia. Porque surgiu? Como se enquadra no contexto da governança territorial do Estado português no continente do país? Que impacto tem vindo a ter no desenvolvimento como Liberdade dos 3 municípios? O método de investigação utilizado foi o estudo de caso. O mesmo contemp...
A Frente Atlântica do Porto é uma associação intermunicipal de fins múltiplos constituída pelos municípios de Matosinhos, Porto e Vila Nova de Gaia. Porque surgiu? Como se enquadra nocontexto da governança territorial do Estado português no continente do país? Que impacto tem vindo a ter no Desenvolvimento como Liberdade dos 3 municípios? O método de investigação utilizado foi o estudo de caso. O mesmo contempl...
This paper presents a solution to the problem of motion control of an autonomous robot, moving in a dynamical and unstable environment. It is based on non-linear dynamical systems, modelling the state variables that define the motion of a robot under an omnidirectional platform, like its direction of navigation and velocity. The approach used, is based on a set of non-linear differential equations that model th...
Theory development is an intrinsic part of science. Radical empiricism is a logical impossibility: the number of phenomena that can be measured and manipulated is infinite, so the very selection of phenomena to investigate must be driven by a priori considerations. Loose facts, moreover, point to nothing but themselves; only theories, even if incipient, have explanatory and predictive power extending beyond pri...