2 documents found, page 1 of 1
Diferenças clínicas entre gêmeas idênticas com anemia falciforme
Laurentino, Marilia Rocha; Almeida Filho, Tarcísio Paulo de; Maia Filho, Pedro A.; Nascimento, Francisco O. F.; Advincula, Adlene F.Sickle cell anemia (SCA) is a genetic disease that causes important clinical manifestations due to chronic hemolysis and vascular occlusion. The aim of this study was to report a rare case of monozygotic twins diagnosed with SCA, presenting a different clinical characteristic. An interview with the patients was carried out and the medical records were consulted. One patient has a history of malleolar ulcer in t...
Double-blind clinical trial of arginine supplementation in the treatment of adu...
Eleutério, Renata Mirian Nunes; Nascimento, Francisco O.; Araújo, Tamara G.; Castro, Marilena F.; Almeida Filho, Tarcísio Paulo de; Maia Filho, Pedro A.Background. Sickle cell anaemia (SCA) is the most prevalentmonogenic disease in Brazil. In SCA, haemoglobin S (HbS) is formed, whichmodifies red blood cell morphology. Intravascular haemolysis occurs, in which free Hb and free radicals degrade nitric oxide (NO) and release arginase, which reduces arginine levels. Because arginine is a substrate for NO formation, this decrease leads to reduced NO (vasodilator) s...