7 documents found, page 1 of 1
Avaliação do risco de desenvolver diabetes mellitus tipo 2 em estudantes do cur...
Figueiredo, Monalisa Feliciano; Maia Filho, Pedro Aurio; Almeida Filho, Tarcísio Paulo de; Laurentino, Marília Rocha; Barbosa, Maritza CavalcanteO Diabetes mellitus (DM) é uma doença metabólica de etiologia múltipla, caracterizada por uma hiperglicemia decorrente de uma alteração na secreção ou ação da insulina. O DM tipo 1 (DM1) está relacionado com a deficiência de insulina resultante da destruição das células-β do pâncreas; o DM tipo 2 (DM2) resulta de um processo fisiopatológico que culmina com a resistência à insulina, sendo o DM2 considerado um pr...
Levothyroxine Replacement Improves Oxidative Status in Primary Hypothyroidism
Masullo, Laís Farias; Magalhães, Rejane Araújo; Lemes, Romélia Pinheiro Gonçalves; Almeida Filho, Tarcísio Paulo de; Castro, Marilena Facundo deObjective: Although hypothyroidism has been linked to oxidative stress, data regarding the relationship between thyroid hormone levels and oxidative stress is still inconsistent. This study was designed to evaluate the effect of levothyroxine replacement on oxidative stress in women with primary hypothyroidism. Design: A total of 25 female patients with primary hypothyroidism were included. Oxidative stress mar...
Genotoxicidade e mutagenicidade em pacientes com leucemia mieloide crônica trat...
Maia Filho, Pedro AurioChronic myelogenous leukemia (CML) is a myeloproliferative disease of hematopoietic stem cells, characterized by the presence of the Philadelphia (Ph) chromosome, originating from a reciprocal translocation between the long arms of chromosomes 9 and 22, forming the gene BCR-ABL, which encodes a BCR-ABL oncoprotein with constitutive tyrosine kinase activity. The clinical course of CML is often divided into three...
Association of oxidative stress and DNA damage with grafting time in patients w...
Santos, Thayna Nogueira dos; Duarte, Fernando Barroso; Maia Filho, Pedro Aurio; Santos, Talyta Ellen de Jesus dos; Barbosa, Maritza CavalcanteSANTOS, Thayna Nogueira .; The aim of the study was to investigate the association between oxidative stress and DNA damage with grafting time in patients submitted to autologous hematopoietic stem-cell transplantation (HSCT). The study included 37 patients submitted to autologous HSCT diagnosed with Multiple Myeloma (MM) and lymphoma (Hodgkin’s and non-Hodgkin’s). Biomarkers of oxidative stress and DNA damage i...
Avaliação da genotoxicidade e mutagenicidade em pacientes com anemia falciforme...
Rodrigues, Ana Beatriz Ferreira; Pereira, Jamilly Florêncio; Maia Filho, Pedro Aurio; Castro, Marilena Facundo; Nunes, Caroline de Fátima Aquino MoreiraRODRIGUES, Ana Beatriz Ferreira; et al. Avaliação da genotoxicidade e mutagenicidade em pacientes com anemia falciforme tratados com hidroxiuréia. Revista Encontros Universitários da UFC, Fortaleza, v. 1, n. 1, 2016. (Encontro de Iniciação Científica, 35); A anemia falciforme (AF), HbSS, é uma doença genética ocasionada por uma mutação pontual no gene da β-globina S. A doença não possui tratamento específico, s...
Clinical events and their relation to the tumor necrosis factor-alpha and inter...
Cavalcante, Jânio Emanuel Andrade; Machado, Rosângela Pinheiro Gonçalves; Laurentino, Marília Rocha; Santos, Talyta Ellen de Jesus dosObjective/background: Sickle-cell anemia (SCA) is a genetic blood disease characterized by chronic inflammation and a heterogeneous clinical picture. Serum tumor necrosis factor (TNF-alpha) and interleukin 10 (IL-10) levels are associated with the clinical course of SCA. This study aimed to evaluate the association between the frequency of the polymorphisms TNF- alpha-308 G ? A, IL-10-1082 G ? A, IL-10-819 C ? ...
Pancytopenia during tyrosine kinase inhibitor treatment–coexistence of chronic ...
Quixada, Acy; Maia Filho, Pedro Aurio; Almeida Filho, Tarcísio Paulo de; Duarte, Fernando Barroso; Moreira-Nunes, Caroline AquinoBackground: Visceral leishmaniasis is a zoonosis characterized by chronic evolution of symptoms; it usually appears 2 to 4 months after the initial infection, with multiple cutaneous lesions and systemic involvement, which if left untreated results in death in 90 % of cases. Case presentation: We present a case of 29-year-old white male farmer, with chronic myeloid leukemia treated with imatinib who developed s...