2 documents found, page 1 of 1
Association of oxidative stress and DNA damage with grafting time in patients w...
Santos,Thayna Nogueira dos; Duarte,Fernando Barroso; Maia Filho,Pedro Aurio; Santos,Talyta Ellen de Jesus dos; Barbosa,Maritza CavalcanteABSTRACT The aim of the study was to investigate the association between oxidative stress and DNA damage with grafting time in patients submitted to autologous hematopoietic stem-cell transplantation (HSCT). The study included 37 patients submitted to autologous HSCT diagnosed with Multiple Myeloma (MM) and lymphoma (Hodgkin’s and non-Hodgkin’s). Biomarkers of oxidative stress and DNA damage index (DI) were per...
Influence of ?S-globin haplotypes and hydroxyurea on tumor necrosis factor-alph...
Laurentino,Marília Rocha; Maia Filho,Pedro Aurio; Barbosa,Maritza Cavalcante; Bandeira,Izabel Cristina Justino; Rocha,Lilianne Brito da SilvaBackground: Sickle cell anemia is a chronic inflammatory disease characterized by an increased production of proinflammatory cytokines including tumor necrosis factor-alpha. Hydroxyurea, by decreasing the polymerization of hemoglobin, reduces inflammatory states. The effect of the genetic polymorphisms of sickle cell patients on tumor necrosis factor-alpha levels remains unknown. Objective: The aim of this stud...