2 documents found, page 1 of 1
An integrative skeletal and paleogenomic analysis of stature variation suggests...
Marciniak, Stephanie; Bergey, Christina M.; Silva, Ana Maria; Hałuszko, Agata; Furmanek, Mirosław; Veselka, Barbara; Velemínský, PetrHuman culture, biology, and health were shaped dramatically by the onset of agriculture ∼12,000 y B.P. This shift is hypothesized to have resulted in increased individual fitness and population growth as evidenced by archaeological and population genomic data alongside a decline in physiological health as inferred from skeletal remains. Here, we consider osteological and ancient DNA data from the same prehistor...
Improving genetic prediction by leveraging genetic correlations among human dis...
Maier, Robert M.; Zhu, Zhihong; Lee, Sang Hong; Trzaskowski, Maciej; Ruderfer, Douglas M.; Stahl, Eli A.; Ripke, Stephan; Wray, Naomi R.; Yang, JianGenomic prediction has the potential to contribute to precision medicine. However, to date, the utility of such predictors is limited due to low accuracy for most traits. Here theory and simulation study are used to demonstrate that widespread pleiotropy among phenotypes can be utilised to improve genomic risk prediction. We show how a genetic predictor can be created as a weighted index that combines published...