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Impaired executive functions in experimental model of temporal lobe epilepsy
Ramos,Fabiane Ochai; Carreiro,Luiz Renato Rodrigues; Scorza,Fulvio Alexandre; Cysneiros,Roberta MonterazzoABSTRACT Objective The present study aimed to investigate cognitive and behavioural changes consistent with attention deficit hyperactivity disorder (ADHD -like behavior in male Wistar rats with temporal lobe epilepsy (TLE). Method Male Wistar rats at 25 day of age were submitted to animal model of TLE by pilocarpine injection (350 mg/kg, ip) and a control group received saline 0.9%. The animals were continuous...
The promise of omega-3 against sudden unexpected death in epilepsy: until furth...
Scorza,Fulvio Alexandre; Lopes,Antonio Carlos; Cysneiros,Roberta Monterazzo; Arida,Ricardo Mario; Silva,Maurício Rocha eThe present paper highlighted the importance of the recommended levels of fish consumption or omega-3 supplementation in order to minimize the frequency of seizures in people with uncontrolled epilepsy and, especially, to reduce the occurrence of sudden unexpected death in epilepsy (SUDEP).
Omega-3 intake in people with epilepsy under regular hemodialysis program: here...
Scorza,Carla Alessandra; Arida,Ricardo Mario; Cysneiros,Roberta Monterazzo; Cavalheiro,Esper Abrão; Scorza,Fulvio AlexandreAmong the many risk factors suggested for sudden unexpected death in epilepsy (SUDEP), higher frequency of seizures is a very consistent issue. Furthermore, it has been established that hemodialysis-associated seizure is a complication of the dialysis procedure. Thus, since a possible relation between cardiovascular abnormalities and SUDEP among patients with chronic renal insufficiency in regular hemodialysis ...
Serum levels of magnesium in sudden cardiac deaths among people with schizophre...
Scorza,Fulvio A.; Albuquerque,Marly de; Arida,Ricardo M.; Cysneiros,Roberta MonterazzoSchizophrenia is a devastating mental disorder, affecting cognitive, emotional, and behavioral conditions, ability to work, social functioning, family stability and self-esteem of the patient. People with schizophrenia show a two to three-fold increased risk to die prematurely than those without schizophrenia. Understanding the mechanisms behind sudden cardiac death in individuals with schizophrenia is a key to...
Physical exercise in rats with epilepsy is protective against seizures: evidenc...
Arida,Ricardo Mario; Scorza,Fulvio Alexandre; Terra,Vera Cristina; Cysneiros,Roberta Monterazzo; Cavalheiro,Esper AbrãoPeople with epilepsy have been discouraged from participating in physical activity due to the fear that it will exacerbate seizures. Clinical and animal studies indicate a reduction of seizure frequency as well as decrease susceptibility to subsequently evoked seizures after an exercise program. Analyses from experimental studies of animals with epilepsy submitted to physical training programs were performed. I...
Níveis cardíacos de troponina I em pacientes com epilepsia do lobo temporal ref...
Colugnati,Diego Basile; Cukiert,Arthur; Matos,Wilna Klecia Lima; Albuquerque,Marly de; Arida,Ricardo Mario; Cavalheiro,Esper AbrãoOBJETIVOS: A morte súbita em epilepsia (SUDEP) é a principal causa de morte entre os pacientes com epilepsia. Alterações morfológicas e funcionais do coração estão relacionadas com a SUDEP. Nesse sentido, o objetivo deste estudo foi avaliar a concentração de troponina I, um importante marcador de lesão do miocárdio, em pacientes com epilepsia do lobo temporal de difícil controle e que foram submetidos à ressecç...
Seizure occurrence in patients with chronic renal insufficiency in regular hemo...
Scorza,Fulvio Alexandre; Albuquerque,Marly de; Arida,Ricardo Mario; Cysneiros,Roberta Monterazzo; Henriques,Tânia Maria Guedes; Scorza,Carla AlessandraHemodialysis-associated seizure is a complication of hemodialysis. This report describes the occurrence of seizures in patients with end stage renal disease on dialysis therapy at the Nephrology Institute of Mogi das Cruzes, São Paulo State, Brazil. A retrospective medical history of 189 patients was reviewed to investigate the occurrence of convulsive seizures during dialytic program. Seven patients with histo...
Lovastatin reduces neuronal cell death in hippocampal CA1 subfield after piloca...
Rangel,Pauline; Cysneiros,Roberta Monterazzo; Arida,Ricardo Mario; Albuquerque,Marly de; Colugnati,Diego Basile; Scorza,Carla AlessandraOBJECTIVE: To further characterize the capacity of lovastatin to prevent hippocampal neuronal loss after pilocarpine-induced status epilepticus (SE) METHOD: Adult male Wistar rats were divided into four groups: (A) control rats, received neither pilocarpine nor lovastatin (n=5); (B) control rats, received just lovastatin (n=5); (C) rats that received just pilocarpine (n=5); (D) rats that received pilocarpine an...
Avaliação de parâmetros cardíacos em animais com epilepsia: possível causa de m...
Colugnati,Diego Basile; Gomes,Paulo Alberto Paes; Arida,Ricardo Mario; Albuquerque,Marly de; Cysneiros,Roberta Monterazzo; Cavalheiro,Esper AbrãoDentre as causas de morte súbita nas epilepsias (SUDEPE), as disfunções cardíacas têm sido uma área de interesse. Sendo assim, o objetivo de nosso estudo foi avaliar a freqüência cardíaca (FC) (in vivo e in vitro) e a pressão ventricular (PV) in vitro de ratos com epilepsia induzida pela pilocarpina. Ratos machos, adultos, da raça Wistar (n=6) receberam pilocarpina para a indução do status epilepticus. Ratos co...
Estudo qualitativo da formação hipocampal de animais hipertensos com epilepsia
Scorza,Fulvio Alexandre; Arida,Ricardo Mario; Cysneiros,Roberta Monterazzo; Scorza,Carla Alessandra; Albuquerque,Marly de; Cavalheiro,Esper AbrãoO objetivo deste estudo foi avaliar qualitativamente o hipocampo e o giro dentado de ratos espontaneamente hipertensos (SHR) com epilepsia. MÉTODO: Os animais foram divididos em 4 grupos: Wistar controle, Wistar com epilepsia, SHR controle e SHR com epilepsia. Para indução da epilepsia, utilizamos o modelo da pilocarpina. Após os animais apresentarem crises espontâneas e recorrentes, o tecido cerebral dos anima...