5 documents found, page 1 of 1
Immune-related serious adverse events with immune checkpoint inhibitors: system...
Oliveira, Clara; Mainoli, Beatrice; Duarte, Gonçalo Silva; Machado, Tiago; Tinoco, Rita G.; Esperança Martins, Miguel; Ferreira, Joaquim J; Costa, JoãoPurpose: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, though uncertainty exists regarding their immune-related safety. The objective of this study was to assess the comparative safety profile (odds ratio) of ICIs and estimate the absolute rate of immune-related serious adverse events (irSAEs) in cancer patients undergoing treatment with ICIs. Methods: We searched for randomized tria...
The Landscape of Non-Melanoma Skin Cancer in Portugal
Ascenção, Raquel; Silva, João Maia; Borralho, Paula; Correia, Miguel; Correia, Osvaldo; Costa, João; Machado, Tiago; Mainoli, Beatrice; Sampaio, FilipaIntroduction: Non-melanoma skin cancer (NMSC) includes several types of skin cancer, with the most common types of tumors being basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The current study aims to describe the landscape of NMSC in Portugal, based on real world data from both the public and private sectors.Methods: Two sub-studies are included in this work. In sub-study one, hospital episode s...
Analysis of clinical and methodological characteristics of early COVID-19 treat...
Mainoli, Beatrice; Machado, Tiago; Duarte, Gonçalo Silva; Prada, Luísa; Gonçalves, Nilza; Ferreira, Joaquim J; Costa, JoãoBackground: The COVID-19 pandemic continues to rage on, and clinical research has been promoted worldwide. We aimed to assess the clinical and methodological characteristics of treatment clinical trials that have been set forth as an early response to the COVID-19 pandemic. Methods: First, we reviewed all registered clinical trials on COVID-19. The World Health Organization International Trials Registry Platfor...
Once- versus twice-daily aspirin in patients at high risk of thrombotic events ...
Mainoli, Beatrice; Duarte, Gonçalo S.; Costa, João; Ferreira, Joaquim J.; Caldeira, DanielBackground: Acetylsalicylic acid (ASA) is a frequently used antiplatelet agent, although some individuals have reduced antiplatelet responses on ASA, with recurrent ischemic events. It has been proposed that shortening the ASA dosing interval may overcome the time-dependent renewal of the drug target, leading to a greater antiplatelet efect. We conducted a systematic review of randomized controlled trials (RCTs...
Nocebo response in Parkinson's disease : a systematic review and meta-analysis
Leal Rato, Miguel; Duarte, Gonçalo Silva; Nunes-Ferreira, Afonso; Alves, Mariana; Mainoli, Beatrice; Teodoro, Tiago; Mestre, Tiago; Costa, JoãoObjective: To estimate the magnitude of the nocebo response in Parkinson's disease and explore possible associations with study characteristics. Methods: Databases were searched up to February 2017. Placebo-controlled, parallel-group randomized controlled trials investigating pharmacological interventions in people with Parkinson's disease were included. Data were derived from the last measured within-group res...