9 documents found, page 1 of 1
Role of regulatory T cells in irinotecan-induced intestinal mucositis
Fernandes, Camila; Wanderley, Carlos Wagner Souza; Silva, Camila Meireles Souza; Muniz, Heitor Amorim; Teixeira, Maraiza AlvesIntestinal mucositis (IM) is a common side effect of irinotecan-based chemotherapy. The involvement of inflammatory mediators, such as TNF-α, IL1-β, IL-18 and IL-33, has been demonstrated. However, the role of adaptive immune system cells, whose activation is partially regulated by these cytokines, is yet unknown. Thus, we investigated the role of regulatory T cells (Tregs) in irinotecan-induced IM. C57BL/6 mic...
Association of breast cancer with human papillomavirus (HPV) infection in North...
Cavalcante, Jos? Roosevelt; Pinheiro, Luiz Gonzaga Porto; Almeida, Paulo Roberto Carvalho de; Ferreira, M?rcia Val?ria Pitombeira; Cruz, Gizele AlmadaUniversidade Federal Cear?. Faculdade de Medicina. Departamento de Cirurgia e Maternidade Escola Assis Chateaubriand. Fortaleza, CE, Brasil.; Universidade Federal Cear?. Faculdade de Medicina. Departamento de Cirurgia e Maternidade Escola Assis Chateaubriand. Fortaleza, CE, Brasil.; Universidade Federal Cear?. Faculdade de Medicina. Departamento de Patologia e Medicina Legal. Fortaleza, CE, Brasil.; Universidad...
Dual effect of silymarin on experimental non-alcoholic steatohepatitis induced ...
Assis-Júnior, Eudmar Marcolino; Melo, Anielle Torres; Pereira, Venúcia Bruna Magalhães; Wong, Deysi Viviana Tenazoa; Sousa, Nathalia Ribeiro PinhoIrinotecan-based regimens are commonly used for treatment of colorectal cancer, which is limited by mucositis and non-alcoholic steatohepatitis (NASH). Silymarin (SIL) prevents fatty liver disease in the clinical setting and in models of liver damage induced chemically. This study investigated the possible effect of SIL on irinotecan (IRI)-induced NASH. Swiss female mice were injected with saline (SAL 5 ml/kg i...
Interleukin-18 (IL-18) is equally expressed in inflammatory breast cancer and n...
Aguiar, Marco Antônio Nasser; Wanderley, Carlos Wagner S.; Nobre, Lívia Maria Soares; Alencar, Mateus Rolim Mendes AlencarAim: Inflammatory breast cancer (IBC) is the most aggressive form of locally advanced breast can- cer. The signs of inflammation such as hyperemia and hyperthermia might suggest the possible participation of inflammatory mediators. This study investigates stromal and tumor expression of nuclear factor-kappa B (NF-B) and interleukin-18 (IL-18) in samples obtained from IBC and noninflammatory locally advanced breast...
The adaptor protein myd88 is a key signaling molecule in the pathogenesis of ir...
Wong, Deysi V. T.; Lima-Júnior, Roberto C. P.; Carvalho, Cibele B. M.; Borges, Vanessa F.; Wanderley, Carlos W. S.; Bem, Amanda X. C.Intestinal mucositis is a common side effect of irinotecan-based anticancer regimens. Mucositis causes cell damage, bacterial/endotoxin translocation and production of cytokines including IL–1 and IL–18. These molecules and toll-like receptors (TLRs) activate a common signaling pathway that involves the Myeloid Differentiation adaptor protein, MyD88, whose role in intestinal mucositis is unknown. Then, we evalu...
Development of a subcutaneous endometriosis rat model
Pereira, Francisco Edson Ximenes Gomes; Almeida, Paulo Roberto Carvalho de; Dias, Bruno Hállan Meneses; Vasconcelos, Paulo Roberto Leitão dePURPOSE: To present a rat model of subcutaneous endometriosis for the study of pathophysiology and the effects of drugs. METHODS: Fifty three-month-old female Wistar rats (Rattus norvergicus) were distributed into one control group and four treatment groups: estradiol (2.5; 5; 10mg/kg sc), medroxyprogesterone acetate (0.5; 2; 5mg/kg sc), triptorelin pamoate (0.18; 0.56mg/kg sc) and acetylsalicylic acid (3mg/kg ...
Repercussão hepática da carcinogênese colorretal induzida pelo azoximetano
Burlamaqui, Idália Maria Brasil; Dornelas, Conceição Aparecida; Almeida, Paulo Roberto Carvalho de; Jamacaru, Francisco Vagnaldo FechineObjetivo: Avaliar as repercussões hepáticas da carcinogênese colônica induzida por diferentes doses e tempos de exposição ao azoximetano em ratos Wistar. Métodos: Quarenta e quatro ratos foram distribuídos em quatro grupos. Os animais tinham oito semanas no início do experimento. No grupo 1, receberam 1.0mL de solução salina intraperitonealmente uma vez por semana por duas semanas. No grupo 2, receberam 15 mg/k...
Progressive loss of E-cadherin immunoexpression during cervical carcinogenesis
Cavalcante, José Roosevelt; Sampaio, João Paulo Aguiar; Maia Filho, João Tarcísio Alves; Vieira, Renato Braga; Eleutério Júnior, JoséPURPOSE: To investigate E-cadherin immunoexpression during cervical carcinogenesis. METHODS: We assessed the immunohistochemical expression of E-cadherin in squamous intraepithelial lesions (SIL - 52 cases), squamous cell carcinoma (SCC) of the uterine cervix (23 cases) and also in eight cases of cervicitis. RESULTS: The results show very different E-cadherin membrane expression levels when cervicitis (88%), SI...
Imunoexpressão de ciclooxigenase-2 (COX-2) e caderina-e no câncer gástrico : co...
Almeida, Paulo Roberto Carvalho deBoth COX-2 and E-Cadherin play important roles in physiological and pathological processes in the stomach, such as control of acid secretion, inflammation and cancer. The aim of this study was to analyze the relationship between COX-2 and E-Cadherin immunoexpression in human gastric adenocarcinomas and respective lymph node metastases and their possible action in tumoral progression. Tissue microarrays were pre...