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Directed disruption of IL2 aggregation and receptor binding sites produces desi...

Dashwood, A; Makuyana, N; Kant, R van der; Ghodsinia, A; Hernandez, AR; S, Lienart; Burton, O; Dooley, J; Ali, M; Kouser, L; Naranjo, F; Holt, MG

The pleotropic nature of interleukin-2 (IL2) has allowed it to be used as both a pro-inflammatory and anti-inflammatory therapeutic agent, through promotion of regulatory T cell (Treg) responses via the trimeric IL2RABG receptor or promotion of CD8 T cell responses via the dimeric IL2RBG receptor, respectively. However, the utility of IL2 as a treatment is limited by this same pleiotropy, and protein engineerin...

Date: 2025   |   Origin: Repositório Aberto da Universidade do Porto
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