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Health status assessment through scales and questionnaires: an important tool i...
Rosa, Ilka Martins; Valois, Rachel; Monteiro, Gustavo; Guedes, LaraThe development of measurement instruments is an important tool in epidemiological studies. During the preparation of a scientific study protocol, the collection of information is an important step in the research plan. When constructing questionnaires, mastering some concepts is fundamental, such as defining construct, domains, items, and index. How to select the content of the questionnaire? How to write a go...
Exosomal aβ-binding proteins identified by “in silico” analysis represent putat...
Martins, Tânia Soares; Marçalo, Rui; Ferreira, Maria; Vaz, Margarida; Silva, Raquel M.; Rosa, Ilka Martins; Vogelgsang, Jonathan; Wiltfang, JensThe potential of exosomes as biomarker resources for diagnostics and even for therapeutics has intensified research in the field, including in the context of Alzheimer´s disease (AD). The search for disease biomarkers in peripheral biofluids is advancing mainly due to the easy access it offers. In the study presented here, emphasis was given to the bioinformatic identification of putative exosomal candidates fo...
Potential of FTIR spectroscopy applied to exosomes for Alzheimer’s disease disc...
Soares Martins, Tânia; Magalhães, Sandra; Rosa, Ilka Martins; Vogelgsang, Jonathan; Wiltfang, Jens; Delgadillo, Ivonne; Catita, JoséAlzheimer's disease (AD) diagnosis is based on psychological and imaging tests but can also include monitoring cerebrospinal fluid (CSF) biomarkers. However, CSF based-neurochemical approaches are expensive and invasive, limiting their use to well-equipped settings. In contrast, blood-based biomarkers are minimally invasive, cost-effective, and a widely accessible alternative. Blood-derived exosomes have recent...
Characterization of a primary care based Cohort in the Aveiro region of Portugal
Rosa, Ilka MartinsEuropean Health reports from the World Health Organization reveal that life expectancy is steadily increasing. Dementia and depression are among the pathologies that most affect the elderly; a frail population, with limited resources and funds. Often the first point of contact for these patients is the family doctor in primary health care settings. With this in mind the overall goal of this thesis was to implem...