12 documents found, page 1 of 2
A tetravalent dengue nanoparticle stimulates antibody production in mice.
Silva, Elisângela; Orsi, Mariana; Andrade, Ângela Leão; Domingues, Rosana Zacarias; Silva, Breno de Mello; Araújo, Helena deDengue is a major public health problem worldwide, especially in the tropical and subtropical regions of the world. Infection with a single Dengue virus (DENV) serotype causes a mild, self-limiting febrile illness called dengue fever. However, a subset of patients experiencing secondary infection with a different serotype progresses to the severe form of the disease, dengue hemorrhagic fever/dengue shock syndro...
Avaliação protéica de uma nova multimistura com base no milho QPM BR 473.
Glória, Enara Cristina Silva; Almeida, Nízia Araújo Vieira; Costa, Alexandre Sylvio Vieira da; Henriques Júnior, Edinete; Martins, Sandra LagattaA multimistura tem sido utilizada no Brasil pela Pastoral da Criança, em parceria com governos municipais, a fim de reduzir a desnutrição infantil. Não obstante, a eficácia deste suplemento tem sido constantemente arguida, devido à possível presença de fatores antinutricionais. No presente trabalho descrevemos a avaliação biológica de um suplemento contendo milho QPM BR473. Trinta e seis ratos Wistar machos, co...
Biological evaluation of a nutritional supplement prepared with QPM Maize culti...
Paula, Heberth de; Santos, Rinaldo Cardoso dos; Silva, Marcelo Eustáquio; Glória, Enara Cristina Silva; Pedrosa, Maria LúciaQuality Protein Maize (QPM) cultivar BR 473 was employed, together with soybean flour, brown sugar, banana meal and oat meal, for the preparation of a nutritional supplement.. 21-day old male Fisher rats were fed diets containing the supplement as a protein source, both with and without soybean flour; casein diets with 10 or 7% protein served as respective controls. Protein Efficiency Ratio (PER), Net Protein U...
PREVALENCE OF PARACOCCIDIOIDOMYCOSIS INFECTION BY INTRADERMAL REACTION IN RURAL...
Magalhães, Evandro Monteiro de Sá; Ribeiro, Carla de Fátima; Dâmaso, Carla Silva; Coelho, Luiz Felipe Leomil; Silva, Roberta RibeiroThis study aimed to estimate the prevalence of paracoccidioidal infection by intradermal reaction (Delayed-Type Hypersensitivity, DTH) to Paracoccidioides brasiliensis in rural areas in Alfenas, Southern Minas Gerais (MG) State, Brazil, and to assess risk factors (gender, occupation, age, alcohol intake and smoking) associated with infection. We conducted a population-based cross-sectional study using intraderm...
Descriptive study of American tegumentary leishmaniasis in the urban area of th...
Miranda, Thiago Mourão de; Malaquias, Luiz Cosme Cotta; Escalda, Patrícia Maria Fonseca; Ramalho, Katiuscia Cardoso; Vital, Wendel CouraTo understand the emergence and re-emergence pattern of American tegumentary leishmaniasis (ATL), the clinical and epidemiological profiles and the spatial distribution of the disease were evaluated between 2001 and 2006 in an endemic area located in the Rio Doce valley in the north-eastern part of the Minas Gerais State, Brazil. The number of reported cases increased from six in the first year to 111 in the la...
Descriptive study of American tegumentary leishmaniasis in the urban area of th...
Miranda, Thiago Mourão de; Malaquias, Luiz Cosme Cotta; Escalda, Patrícia Maria Fonseca; Ramalho, Katiuscia Cardoso; Coura-Vital, WendelPara entender os padrões de emergência e re-emergência da leishmaniose tegumentar americana (LTA), foram avaliados os perfis clínico e epidemiológico e a distribuição espacial da doença entre 2001 e 2006 em uma área endêmica situada no vale do Rio Doce, no nordeste do Estado de Minas Gerais, Brasil. O número de casos notificados aumentou de seis, no primeiro ano, para 111 no último ano do período estudado. Os c...
Immunological changes in canine peripheral blood leukocytes triggered by immuni...
Araújo, Márcio Sobreira Silva; Andrade, Renata Aline de; Avelar, Renato Sathler; Magalhães, Camila Paula; Carvalho, Andréa Teixeira deIn this study, we summarized the major phenotypic/functional aspects of circulating leuko-cytes following canine immunization with Leishvaccine and Leishmune ®. Our findings showed that Leishvaccine triggered early changes in the innate immunity (neutrophils and eosinophils) with late alterations on monocytes. Conversely, Leishmune ® induced early phenotypic changes in both, neutrophils and monocytes. Moreover,...
Histological study of cell migration in the dermis of hamsters after immunisati...
Moreira, Nádia das Dores; Giunchetti, Rodolfo Cordeiro; Carneiro, Cláudia Martins; Souza, Juliana Vitoriano de; Roatt, Bruno MendesVaccine candidates, including live and/or killed parasites, Leishmania -purified fractions, defined recombinant antigens and antigen-encoding DNA-plasmids have been proposed to use as vaccine anti- Leishmania . More recently, the hamsters have been used to pre selection of antigens candidate to apply in further experiments using canine model. In this report we evaluated the kinetics of cell migration in dermal ...
Immunogenicity of a killed Leishmania vaccine with saponin adjuvant in dogs.
Giunchetti, Rodolfo Cordeiro; Oliveira, Rodrigo Corrêa de; Martins Filho, Olindo Assis; Carvalho, Andréa Teixeira de; Roatt, Bruno MendesCellular and humoral immune responses of dogs to a candidate vaccine, composed of Leishmania braziliensis promastigote protein plus saponin as adjuvant, have been investigated as a pre-requisite to understanding the mechanisms of immunogenicity against canine visceral leishmaniasis (CVL). The candidate vaccine elicited strong antigenicity related to the increases of anti- Leishmania IgG isotypes, together with ...
T-cell-derived cytokines, nitric oxide production by peripheral blood monocytes...
Araújo, Márcio Sobreira Silva; Andrade, Renata Aline de; Avelar, Renato Sathler; Carvalho, Andréa Teixeira de; Andrade, Mariléia ChavesIt is generally accepted that distinct cytokine expression by the cellular immune response plays a critica role during the outcome of experimental as well as natural canine visceral Leishmaniasis (CVL). Despite the fact that immunoprophylaxis of CVL has become an important control strategy and protective immunity has been reported upon immunization with whole as well as purifiedLeishmaniaantigens, the cytokine ...