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Polymorphisms in the CIITA −168A/G (rs3087456) and CIITA +1614G/C (rs4774) may ...
Pereira,Valéria Coelho Santa Rita; Fontes-Dantas,Fabrícia Lima; Paradela,Eduardo Ribeiro; Malfetano,Fabíola RachidABSTRACT It is currently unknown how genetic factors may influence the clinical course of multiple sclerosis (MS). Objective: We examined the impact of CIITA polymorphisms −168A/G (rs3087456) and +1614G/C (rs4774) on the risk of disability progression, severity and on responses to first-line immunomodulator treatments. Methods: Genomic DNA was extracted from blood samples. We used ABI3730xl and GeneMapper v.4.0...
Natalizumab adverse events are rare in patients with multiple sclerosis
Fragoso,Yára Dadalti; Alves-Leon,Soniza Vieira; Arruda,Walter Oleschko; Carvalho,Margarete de Jesus; Comini-Frota,Elizabeth Regina; Corrêa,Éber CastroObjective To assess the prevalence and the profile of adverse events (AE) of natalizumab in patients with multiple sclerosis (MS). Methods Data collection from neurologists attending to patients with MS at specialized units in Brazil. Results Data from 103 patients attending the infusion centers of 16 MS units in 9 Brazilian states were included in the study. The total number of infusions was 1,042. Seventy-nin...
Clinical response to interferon beta and glatiramer acetate in multiple scleros...
Pereira,Valéria Coelho Santa Rita; Malfetano,Fabíola Rachid; Meira,Isabella D'Andrea; Souza,Letícia Fêzer de; Liem,Assuncion Martinez; Maiolino,AngeloINTRODUCTION: Many patients with multiple sclerosis (MS) are currently receiving treatment with interferon beta (IFNb) and glatiramer acetate (GA). Identifying nonresponders patients is important to define therapy strategies. Several criteria for treatment response to IFNb and GA have been proposed. OBJECTIVE: It was to investigate the response to treatment with IFNb-1a, IFNb-1b and GA among relapsing-remitting...
Acute disseminated encephalomyelitis: clinical features, HLA DRB1*1501, HLA DRB...
Alves-Leon,Soniza Vieira; Veluttini-Pimentel,Maria Lucia; Gouveia,Maria Emmerick; Malfetano,Fabíola Rachid; Gaspareto,Emerson L.; Alvarenga,Marcos P.We evaluated the frequency, demographic, clinical, disability evolution and genetic association of HLA DRB1*1501, DRB1*1503, DQA1*0102, DQB1*0602 and DPA1*0301 alleles in patients diagnosed as acute disseminated encephalomyelitis (ADEM) among a population of CNS demyelinating diseases. Fifteen patients (8.4%) of our series were diagnosed as ADEM. The mean age onset was 35.23 years (range 12 to 77), 53.3% were m...
Multiple sclerosis outcome and morbi-mortality of a Brazilian cohort patients
Alves-Leon,Soniza Vieira; Malfetano,Fabíola Rachid; Pimentel,Maria Lucia Veluttini; Estrada,Claudio Luiz Duque; Pereira,Valéria Coelho Santa RitaWe studied the clinical and evolution characteristics of multiple sclerosis (MS) patients followed since the onset of HUCFF/UFRJ in 1978. The diagnosis of MS was based on Poser's et al. and MC Donald's et al. criteria. From 188 patients, 122 were included. Eighty-five were females. The mean age onset was 32.2 years-old (range 6.0 to 61.0±10.3), mainly Caucasians (82/67%). The relapsing-remitting course (MSRR) w...
Immune system markers of neuroinflammation in patients with clinical diagnose o...
Alves-Leon,Soniza Vieira; Pimentel,Maria Lucia Vellutini; Sant'Anna,Gabrielle; Malfetano,Fabíola Rachid; Estrada,Cláudio Duque; Quirico- Santos,TherezaNeuromyelitis optica (NMO) is an inflammatory, demyelinating disease of the central nervous system characterized by the association of a serious myelitis and unilateral or bilateral optic neuritis. The present study aimed to analyze the immunological parameters of NMO patients with diagnosis established based on Wingerchuck et al. (1999) criteria. Production of IgG and IgA antibodies to antigens of MBP, PLP 95-...