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Optimized in-solution enrichment over a million ancient human SNPs

Davidson, Roberta; Roca-Rada, Xavier; Ravinshakar, Shyamsundar; Taufik, Leonard; Haarkötter, Christian; Collen, Evelyn; Williams, Matthew P.

Background In-solution hybridization enrichment of genetic markers is a method of choice in paleogenomic studies, where the DNA of interest is generally heavily fragmented and contaminated with environmental DNA, and where the retrieval of genetic data comparable between individuals is challenging. Here, we benchmark the commercial “Twist Ancient DNA” reagent from Twist Biosciences using sequencing libraries fr...


β-Tricalcium Phosphate Interferes with the Assessment of Crystallinity in Burne...

Piga, Giampaolo; Amarante, Ana; Makhoul, Calil; Cunha, Eugénia; Malgosa, Assumpció; Enzo, Stefano; Gonçalves, David

The analysis of burned remains is a highly complex process, and a better insight can be gained with advanced technologies. The main goal of this paper is to apply X-ray diffraction, partially supported by infrared attenuated total reflectance spectroscopy to determine changes in burned human bones and teeth in terms of mineral phase transformations. Samples of 36 bones and 12 teeth were heated at 1050°C and aft...


La Menorca talayótica desde el punto de vista genético: la necrópolis de la Cov...

Simón, Marc; Armentano, Núria; Afonso, Cristina; Malgosa, Assumpció

En el presente artículo se estudian las características genéticas de la población del yacimiento talayótico de la Cova des Pas, que revelan una importante endogamia a nivel de ADN mitocondrial. La comparación con otras series contemporáneas de las Islas Baleares permite hipotetizar la existencia de grupos cerrados, con limitados linajes femeninos y necrópolis de difícil acceso, como esta. Tales comunidades cont...


A structural approach in the study of bones: fossil and burnt bones at nanosize...

Piga, Giampaolo; Baró, Maria Dolors; Escoval, Irati Golvano; Gonçalves, David; Makhoul, Calil; Amarante, Ana; Malgosa, Assumpció; Enzo, Stefano

We review the different factors affecting significantly mineral structure and composition of bones. Particularly, it is assessed that micro-nanostructural and chemical properties of skeleton bones change drastically during burning; the micro- and nanostructural changes attending those phases manifest themselves, amongst others, in observable alterations to the bones colour, morphology, microstructure, mechanica...


Understanding the Crystallinity Indices Behavior of Burned Bones and Teeth by A...

Piga, Giampaolo; Gonçalves, David; Thompson, Tim T. J. U.; Brunetti, Antonio; Malgosa, Assumpció; Enzo, Stefano

We have critically investigated the ATR-IR spectroscopy data behavior of burned human teeth as opposed to the generally observed behavior in human bones that were subjected to heat treatment, whether deliberate or accidental. It is shown that the deterioration of the crystallinity index (CI) behavior sometimes observed in bones subjected to high temperature appears to be of higher frequency in the case of bioap...


Influencia de las patologías en los indicadores de edad adulta del coxal: estud...

Rissech, Carme; Schmitt, Aurore; Malgosa, Assumpció; Cunha, Eugénia

Para valorar la incidencia de algunas patologías (artritis reumatoide, artritis crónica juvenil, espondilitis anquilosante, artritis psoriásica, síndrome de Reiter, y tuberculosis ) en los indicadores de edad del coxal adulto, se realizó una revisión bibliográfica de los datos clínicos actuales. También se analizó la relación de la pérdida ósea de las variables de la superficie auricular y el acetábulo. Para el...


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