4 documents found, page 1 of 1
Algoritmos de inteligência artificial para diagnóstico do cancro da próstata
Pinho, Bia; Vale, João; Malhão, Fernanda; Silva, ReginaO cancro da próstata (CP) é o segundo tipo de cancro mais incidente nos homens. O diagnóstico histológico está sujeito à subjetividade e variabilidade interobservador pois baseia-se no reconhecimento visual de padrões morfológicos. A Patologia Digital e a aplicação de algoritmos de Inteligência Artificial (IA) às imagens digitais podem auxiliar os patologistas, reduzindo a subjetividade, permitindo um diagnósti...
Effects and Mechanisms of Action of Preussin, a Marine Fungal Metabolite, again...
Seabra, Rosária; Malhão, Fernanda; Correia, Alexandra; Costa, Carla; Kijjoa, Anake; Rocha, EduardoTriple-negative breast cancer (TNBC) represents an aggressive subtype of breast cancer (BC) with a typically poorer prognosis than other subtypes of BC and limited therapeutic options. Therefore, new drugs would be particularly welcome to help treat TNBC. Preussin, isolated from the marine sponge-associated fungus, Aspergillus candidus, has shown the potential to reduce cell viability and proliferation as well ...
Fucoxanthin Holds Potential to Become a Drug Adjuvant in Breast Cancer Treatmen...
Malhão, Fernanda; Macedo, Ana Catarina; Costa, Carla; Rocha, Eduardo; Ramos, Alice AbreuFucoxanthin (Fx) is a carotenoid derived from marine organisms that exhibits anticancer activities. However, its role as a potential drug adjuvant in breast cancer (BC) treatment is still poorly explored. Firstly, this study investigated the cytotoxic effects of Fx alone and combined with doxorubicin (Dox) and cisplatin (Cis) on a panel of 2D-cultured BC cell lines (MCF7, SKBR3 and MDA-MB-231) and one non-tumor...
Sex-steroids and hypolipidemic chemicals impacts on brown trout lipid and perox...
Madureira, Tânia Vieira; Malhão, Fernanda; Simões, Tiago; Pinheiro, Ivone; Lopes, Célia; Gonçalves, José F.; Urbatzka, Ralph; Castro, L. Filipe C.Lipid metabolism involves complex pathways, which are regulated in a similar way across vertebrates. Hormonal and hypolipidemic deregulations cause lipid imbalance from fish to humans, but the underlying mechanisms are far from understood. This study explores the potential of using juvenile brown trout to evaluate the in vivo interferences caused by estrogenic (17α-ethinylestradiol - EE2), androgenic (testoster...