17 documents found, page 1 of 2
Clinical implications of anti-HLA antibodies testing in kidney transplantation
Malheiro, J.; Tafulo, S.Alloantibodies against donor human leukocyte antigens (HLA), termed as donor‑specific antibodies (DSA), are one of the most important factors for both early and late kidney allograft dysfunction. In the past, these antibodies were mainly detected through cell‑based crossmatch tests. Recently, new techniques such as solid phase immunoassays (SPI) have revealed these antibodies in patient sera with a high degree ...
Acute tubulointersticial nephritis with uveitis: A report of two cases
Silva, F.; Correia, S.; Castro, A.; Moreira, C.; Santos, S.; Malheiro, J.; Santos, J.; Martins, L.; Cabrita, A.Tubulointersticial nephritis and uveitis syndrome is an idiopathic and rare cause of acute kidney injury that should not overlooked, because it usually requires specific therapeutic interventions. We report two distinct cases: a young and an elder female. Both cases presented with unspecific constitutional symptoms but had different onset of renal and ocular involvement. Both were treated with topical and syste...
Monoclonal gammopathy of renal significance: Diagnostic workup
Correia, S.; Santos, S.; Malheiro, J.; Cabrita, A.; Martins, L.; Santos, J.The clinical spectrum of diseases associated with monoclonal gammopathies is wide and they are most commonly the consequence of renal deposition of monoclonal immunoglobulin or its components. The differential diagnosis is difficult and renal biopsy is essential. To distinguish many of these pathologies is necessary to use techniques that are not always available, even in tertiary central hospitals. This review...
Implications for patients waiting for a kidney transplant of using the calculat...
Magriço, R.; Malheiro, J.; Tafulo, S.; Pedroso, S.; Almeida, M.; Martins, L.; Dias, L.; Castro-Henriques, A.; Cabrita, A.Introduction: Kidney transplant improves survival even in highly‑sensitized (HS) patients. To overcome their disadvantage in accessing transplantation, those with high Complement Dependent Cytotoxic PRA (CDC‑PRA) receive additional points during allocation. Whether this strategy reaches all HS patients and how long they wait for a transplant is largely undetermined. Methods: Patients on our unit’s active wait‑l...
Impact of preformed donor-specific antibodies against HLA class I on kidney gra...
Santos, S.; Malheiro, J.; Tafulo, S.; Dias, L.; Carmo, R.; Sampaio, S.; Costa, M.; Campos, A.; Pedroso, S.; Almeida, M.; Martins, L.; Henriques, C.AIM: To analyze the clinical impact of preformed antiHLA-Cw vs antiHLA-A and/or -B donor-specific antibodies (DSA) in kidney transplantation. METHODS: Retrospective study, comparing 12 patients transplanted with DSA exclusively antiHLA-Cw with 23 patients with preformed DSA antiHLA-A and/or B. RESULTS: One year after transplantation there were no differences in terms of acute rejection between the two groups (3...
Impact of pre-transplant anti-MICA sensitization in graft rejection and survival
Costa, R.; Malheiro, J.; Tafulo, S.; Santos, C.; Almeida, M.; Pedroso, S.; Martins, L.; Dias, L.; Castro-Henriques, A.Background: Evidence supporting deleterious effect of preformed major histocompatibility class I chain-related A (MICA) antibodies in rejection incidence and graft survival is still unclear. Methods: Retrospective analysis of 554 kidney transplanted patients. Comparison between positive or negative for MICA antibodies patients was performed to characterize sensitizing triggers. Further classification according ...
Peritoneal dialysis dropouts in different age and era cohorts: focus on the eld...
Campos, A.; Malheiro, J.; Teixeira, L.; Carvalho, M.; Cabrita, A.; Rodrigues, A.Introduction and Aims: Peritoneal dialysis (PD) is an efficient renal replacement therapy (RRT), but still remains underutilized at any age. Clinicians fear the rate of dropouts and lower technique survival, particularly in elderly patients. The authors aimed to explore such outcomes over the past 3 decades, in different age and era cohorts. Methods: Consecutive incident patients starting PD were identified fro...
Mesalazine induced tubulointersticial nephritis
Campos, A.; Santos, S.; Santos, J.; Malheiro, J.; Lobato, L.; Vizcaíno, J.; Cabrita, A.Inflammatory bowel disease and its various treatments may affect the kidney in several ways tubulointersticial nephritis is a rare but serious complication of longer-term mesalazine use. There are few cases reported in the literature. We report the first two cases of mesalazine-induced tubulointersticial nephritis, recently diagnosed in our department. The first one refers to a patient with ulcerous colitis and...
Fgf-23 and vascular calcification in a peritoneal dialysis population with resi...
Santos, S.; Carlos Oliveira, José; Barra, T.; Campos, A.; carvalho, M.; Malheiro, J.; Fonseca, Isabel; Cabrita, A.; Adragão, T.; Rodrigues, AnabelaIntroduction and Aims: Fibroblast growth factor 23 (FGF-23) induces phosphaturia. Its clinical impact is beyond mineral bone disease in chronic kidney disease (CKD), being coupled with vascular calcification and mortality. Residual renal function (RRF) is associated with significant capacity to excrete phosphate in peri- toneal dialysis (PD). Besides testing whether FGF-23 is still related with glomerular filtr...
Effect of sodium hypochlorite on bacteria isolated from drinking water
Gomes, Inês B.; Lemos, M.; Malheiro, J.; Simões, Lúcia C.; Simões, M.Biofilm formation inside drinking water distribution systems (DWDS) constitutes one of the major microbial problems in the distribution of safe water. Biofilms in DWDS can act as a reservoir of pathogenic microorganisms and consequently constitute a threat to public health. Therefore, the control of biofilm development inside the pipes of DWDS is a concern for drinking water companies being the use of chlorine ...