5 documents found, page 1 of 1
Determination of Blood Biomarkers in Mild Traumatic Brain Injury (mTBI), GFAP a...
Lima da Silva, Catarina; Ruivo, Anunciação; Malheiro, Rui; Santos, Lara; Campos, Teresa; Moura, Fernando; Freitas, CarlaIntroduction: Traumatic brain injury (TBI) is one of the most common conditions in the emergency department (ED), representing a public health issue with substantial economic impact. The risk of severe acute intracranial injury increases the need for cranial computed tomography (CT). Serum biomarkers of acute brain injury, such as glial fibrillary acidic protein (GFAP) and ubiquitin carboxyl-terminal hydrolase-...
Mauriac syndrome
Oliveira Torres, João; Martins, Diana; Abegão Matias, Alexandra; Gião, Nuno; Dutra, Eduardo; Malheiro, Rui; Mendes, Milena; Silva-Nunes, Josépersons; Mauriac syndrome is a rare complication in patients with type 1 diabetes. It presents with poor glycemic control and hepatomegaly due to extensive liver glycogen deposition. Whether behavioral or genetic factors play key roles in its pathophysiology remains a subject of debate. We present the case of a 19-year-old woman with poorly controlled type 1 diabetes mellitus and persistently elevated liver enz...
Neurotoxicity Evaluation of Four Structurally Similar Synthetic Cathinones in a...
Fonseca , Catarina da; Malheiro, Rui; Remião, Fernando; Pedro Silva, João; Silva , RenataBackground: Synthetic cathinones are potent central nervous system (CNS) stimulants that induce diverse neurological and psychiatric effects such as delusions, hallucinations, and agitation [1]. This fast-expanding class of new psychoactive substances (NPS) represented the majority of those seized in the European Union in 2021 [2]. Despite the growing recreational use, knowledge on their neurotoxic mechanisms, ...
Two Ancient Diagnostic Procedures in the Same Patient. What are They?
Patrício, Catarina; Malheiro, Rui; Marques, Mariana; Silva, Pedro
Cerebral Creatine Deficiency Syndromes
Malheiro, Rui; Diogo, Luísa; Garcia, Paula; Fineza, Isabel; Oliveira, GuiomarIntroduction: Creatine deficiency syndromes are a recently described group of diseases characterized by inborn errors of creatinemetabolism. Clinical features include a spectrum of neurodevelopment disorders of diverse severity. They are characterized by lowlevels of cerebral creatine caused by different pathogenic mutations concerning the genes coding for creatine synthesis enzymes[arginine: glicyne amidinotra...