20 documents found, page 1 of 2
NAU ‑ New Areas of Unifying Interest for CKD: A Multidisciplinary Expert Opinio...
Malheiro,Jorge; Araújo,Francisco; Nunes,Andreia; Almeida⁵,Clara; Aires,Inês; Nobre,João Pedro; Neves,João Sérgio; Dias,Jordana; Vieira,Miguel BigotteAbstract Introduction: The global prevalence of chronic kidney disease (CKD) is rising exponentially. While patient awareness of CKD remains low, we studied the physicians’ awareness and how globally it can be improved. We aimed to evaluate the awareness and consensus of physicians on the screening, diagnosis and clinical management of CKD, thus identifying which areas should be the subject of educational or re...
Older-to-Older Living Kidney Transplantation: A New Paradigm
Figueiredo,Cátia Raquel; Sousa,Círia; Ventura,Sofia; Cruz,Gonçalo; Almeida,Manuela; Silvano,José; Malheiro,Jorge; Pedroso,Sofia; Martins,La SaleteABSTRACT Older to older living kidney transplantation is an acceptable alternative to avoid dialysis, improve quality of life and maintain favorable long-term outcomes of patients with end-stage kidney disease. However, the management of these patients is complex and the acceptance of older donors and recipients to kidney transplantation remains controversial. The older recipients usually have several comorbidi...
Association between severe chronic kidney disease defined by cystatin-c and cre...
Tavares,Joana; Santos,Josefina; Silva,Filipa; Oliveira,João; Malheiro,Jorge; Campos,Andreia; Cabrita,AntónioABSTRACT Introduction: Estimated glomerular filtration rate (eGFR) based on serum cystatin-C (sCys) seems as accurate as when based on serum creatinine (sCr), but sCys seems a better predictor of adverse outcomes. We aimed to study whether sCys could be a reliable tool for the prediction of adverse outcomes in elderly patients with severe chronic kidney disease (CKD). Methods: A group of 348 elderly patients wi...
ABO-incompatible living donor kidney transplantation in Portugal
Ribeiro,Catarina Isabel; Silva,Natália; Malheiro,Jorge; Almeida,Manuela; Pedroso,Sofia; La Salete Martins,Maria; Dias,Leonídio; Henriques,António CastroIntroduction: ABO incompatibility was considered a barrier to kidney transplant. However, the shortage of available organs for transplantation and the excellent long-term results further establish ABO-incompatible (ABOi) as a safe and effective therapeutic strategy. The aim of the present study was to evaluate the outcomes of ABOi transplantation in terms of graft survival and function, rejection episodes and i...
Validation of a model to predict six-month mortality in incident elderly dialys...
Santos,Josefina; Oliveira,Pedro; Malheiro,Jorge; Campos,Andreia; Correia,Sofia; Cabrita,António; Lobato,Luísa; Fonseca,IsabelBackground and objectives: To evaluate RRT benefits and risks and to inform patients and their families about ESRD treatment options, we have developed a prognostic score to predict 6-month mortality in elderly ESRD patients initiating dialysis. Five independent predictors were identified and a point system was constructed: age 75 years or older (2 points), coronary artery disease (2 points), cerebrovascular di...
Rituximab-induced hypersensitivity pneumonitis in a kidney transplant patient
Silva,Natália; Ribeiro,Catarina Isabel; Almeida,Manuela; Malheiro,Jorge; Pedroso,Sofia; Martins,Maria La Salete; Dias,Leonídio; Henriques,António CastroRituximab (RTX) is a chimeric anti-CD20 monoclonal antibody that has been associated with delayed pulmonary toxicity. In patients receiving RTX, hypersensitivity pneumonitis, although rare, should be considered in the appropriate clinical and radiographic setting. The authors present a case of hypersensitivity pneumonitis associated with a single dose of RTX treatment in a kidney transplanted patient with acute...
Demographic, clinical characteristics and cardiovascular disease burden in a Po...
Lascasas,Josefina Maria Sousa Santos; Fonseca,Isabel; Malheiro,Jorge; Santos,Sofia; Campos,Andreia; Castro,Ana; Moreira,Carla; Correia,SofiaABSTRACT Introduction: Chronic kidney disease (CKD) is an independent risk factor for several unfavorable outcomes including cardiovascular disease (CVD), particularly in the elderly, who represent the most rapidly growing segment of the end-stage kidney disease (ESKD) population. Portugal has the highest European unadjusted incidence and prevalence rates of ESKD. In 2012, we started to follow a cohort of elder...
Severe passenger lymphocyte syndrome associated to Rh antibodies after donor li...
Antunes,Marika Bini; Malheiro,Jorge; Dias,Leonidio; Martins,La Salete; Pedroso,Sofia; Almeida,Manuela; Henriques,Antonio Castro; Amil,MargaridaThe passenger lymphocyte syndrome may cause hemolytic anemia after bone marrow and solid organ transplantation when there is minor erythrocyte antigen incompatibility in the donor/recipient pair. Anemia is usually self-limiting, frequently related to ABO antibodies and rarely to Rh mismatches. We report a rare case of passenger B lymphocyte syndrome mediated by Rh antibodies occurring after a donor living renal...
Clinical implications of anti-HLA antibodies testing in kidney transplantation
Malheiro,Jorge; Tafulo,SandraAlloantibodies against donor human leukocyte antigens (HLA), termed as donor-specific antibodies (DSA), are one of the most important factors for both early and late kidney allograft dysfunction. In the past, these antibodies were mainly detected through cell-based crossmatch tests. Recently, new techniques such as solid phase immunoassays (SPI) have revealed these antibodies in patient sera with a high degree ...
Acute tubulointersticial nephritis with uveitis: A report of two cases
Silva,Filipa; Correia,Sofia O; Castro,Ana; Moreira,Carla; Santos,Sofia; Malheiro,Jorge; Santos,Josefina; Martins,La Salete; Cabrita,AntónioTubulointersticial nephritis and uveitis syndrome is an idiopathic and rare cause of acute kidney injury that should not overlooked, because it usually requires specific therapeutic interventions. We report two distinct cases: a young and an elder female. Both cases presented with unspecific constitutional symptoms but had different onset of renal and ocular involvement. Both were treated with topical and syste...