4 documents found, page 1 of 1
Dual and sequential drug delivery systems with antimicrobial and bone regenerat...
Rodrigues, Miguel A.; Ferreira, Carla; Borges, João P.; Bernardes, Beatriz G.; Oliveira, Ana L.; Santos, José D.; Lopes, Maria A.Bone defect healing is often compromised by infections acquired during surgery, hindering regeneration. An effective solution should first prevent infection and then promote bone repair. Localised drug-delivery systems capable of dual and sequential release of antimicrobial and bone-regenerative agents represent a promising solution; however, precisely controlling this sequential release remains an unmet challe...
Development of a dextrin-based hydrogel for bone regeneration
Silva, Dina M.; Morgado, Daniella L.; Delair, Thierry; David, Laurent; Rouif, Sophie; López-Lacomba, José Luis; Santos, Marta; Maurício, Ana Colette[Excerpt] Bone tissue engineering is a very challenging and promising field, which handles with the limitations of bone regenerative capacity and the failure of current orthopedic implants [1]. This work describes the preparation and characterization of an injectable dextrin-based hydrogel (oDex) able to incorporate nanoparticles, cells, biomolecules or Bonelike~ granules [2]. (...)
Potential of injectable dextrin-based hydrogel for biomedical applications
Silva, Dina M.; Morgado, Daniela; Delair, Thierry; David, Laurent; Rouif, Sophie; López-Lacomba, José Luis; Maurício, Ana Colette; Santos, José D.Bone tissue engineering is a very challenging and promising field, which handles with the limitations of bone regenerative capacity and the failure of current orthopedic implants [1]. This work describes the preparation and characterization of an injectable dextrinbased hydrogel (oDex) through dextrin oxidation followed by cross-linking with a dihydrazide [2]. In vitro and in vivo experiments allowed to conclud...
Application of artificial vascular polyvinyl alcohol hydrogel grafts in sheep -...
Alexandre, Nuno; Gärtner, Andrea; Amorim, Irina; Santos, José D.; Lopes, Maria Ascensão; Colette Maurício, Ana; Luís, Ana LúciaResearchers developed this project according with the tasks originally planned, so far focusing their research activities in the biocompatibility and functionality of vascular implants. The biocompatibility was studied by following the ISO standard 10993-6 for evaluation of medical devices through the evaluation and grading of inflammation caused by implants placed subcutaneously. The implants were placed in sh...