5 documents found, page 1 of 1
Genotoxic effects in occupational exposure to formaldehyde: A study in anatomy ...
Viegas, S; Ladeira, C; Nunes, C; Malta-Vacas, J; Gomes, M; Brito, M; Mendonça, P; Prista, JABSTRACT – Background: According to the Report on Carcinogens, formaldehyde ranks 25th in the overall U.S. chemical production, with more than 5 million tons produced each year. Given its economic importance and widespread use, many people are exposed to formaldehyde environmentally and/or occupationally. Presently, the International Agency for Research on Cancer classifies formaldehyde as carcinogenic to human...
ERF3A/GSPT1 12-GGC allele increases the susceptibility for breast cancer develo...
Malta-Vacas, J; Chauvin, C; Gonçalves, L; Nazaré, A; Carvalho, C; Monteiro, C; Bagrel, D; Jean-Jean, O; Brito, M
Differential expression of the eukaryotic release factor 3 (eRF3/GSPT1) accordi...
Malta-Vacas, J; Aires, C; Costa, P; Conde, AR; Ramos, S; Martins, AP; Monteiro, C; Brito, MBackground: There are now several lines of evidence to suggest that protein synthesis and translation factors are involved in the regulation of cell proliferation and cancer development. Aims: To investigate gene expression patterns of eukaryotic releasing factor 3 (eRF3) in gastric cancer. Methods: RNA was prepared from 25 gastric tumour biopsies and adjacent non-neoplastic mucosa. Real time TaqMan reverse tra...
Modulation of translation factor's gene expression by histone deacetylase inhib...
Goncalves, J; Malta-Vacas, J; Louis, M; Brault, L; Bagrel, D; Monteiro, C; Brito, MThe histone deacetylase inhibitors sodium butyrate (NaBu) and trichostatin A (TSA) exhibit anti-proliferative activity by causing cell cycle arrest and apoptosis. The mechanisms by which NaBu and TSA cause apoptosis and cell cycle arrest are not yet completely clarified, although these agents are known to modulate the expression of several genes including cell-cycle- and apoptosis-related genes. The enzymes inv...
Polyglycine expansions in eRF3/GSPT1 are associated with gastric cancer suscept...
Brito, M; Malta-Vacas, J; Carmona, B; Aires, C; Costa, P; Martins, AP; Ramos, S; Conde, AR; Monteiro, CGastric cancer remains a major cause of death in the developed countries, and a large percentage is still genetically unexplained. Because of their major role in cell survival, mutations in translation factors and altered expression of these genes have been associated with cancer development. Apart from its role in translation termination, the eukaryotic translation release factor 3 (eRF3) is involved in severa...