7 documents found, page 1 of 1
Addressing critical fungal pathogens under a one health perspective: key insigh...
Sabino, R.; Antunes, F.; Araújo, R.; Bezerra, A. R.; Brandão, J.; Carneiro, C.; Carvalho, Agostinho; Carvalho, D.; Conceição, I. C.; Cota Medeiros, F.Fungal infections have emerged as a significant public health concern, especially with the increasing incidence of severe mycoses caused by pathogens such as Aspergillus fumigatus, Candida auris, Candida albicans, and Cryptococcus neoformans. These fungi, listed as critical priorities by the World Health Organization, pose a heightened risk due to rising antifungal resistance and their severe impact on immunoco...
Rare Case of Rickettsiosis Caused by Rickettsia monacensis, Portugal, 2021
de Sousa, R.; Santos, M. L.; Cruz, C.; Almeida, V.; Garrote, A. R.; Ramirez, F.; Seixas, D.; Manata, M.J.; Maltez, F.We report a case of rickettsiosis caused by Rickettsia monacensis in an immunocompetent 67-year-old man in Portugal who had eschar, erythematous rash, and an attached Ixodes ricinus tick. Seroconversion and eschar biopsy led to confirmed diagnosis by PCR. Physicians should be aware of this rare rickettsiosis, especially in geographic regions with the vector.
Non-AIDS-related comorbidities in people living with HIV-1 aged 50 years and ol...
Serrão, R.; Piñero, C.; Velez, J.; Coutinho, D.; Maltez, F.; Lino, S.; Sarmento E Castro, R.; Tavares, A.; Pacheco, P.; Lopes, M.; Mansinho, K.Objective: To characterize the profile of non-AIDS-related comorbidities (NARC) in the older HIV-1-infected population and to explore the factors associated with multiple NARC. Methods: This was a multicentre, cross-sectional study including HIV-1-infected patients aged ≥50 years, who were virologically suppressed and had been on a stable antiretroviral therapy (ART) regimen for at least 6 months. A multiple re...
Multicentre study highlighting clinical relevance of new high-throughput method...
Esteves, F.; Sousa, B. de; Calderón, E. J.; Huang, L.; Badura, R.; Maltez, F.; Bassat, Q.; de Armas, Y.; Antunes, F.; Matos, O.Pneumocystis jirovecii causes severe interstitial pneumonia (PcP) in immunosuppressed patients. This multicentre study assessed the distribution frequencies of epidemiologically relevant genetic markers of P. jirovecii in different geographic populations from Portugal, the USA, Spain, Cuba and Mozambique, and the relationship between the molecular data and the geographical and clinical information, based on a m...
Diagnosis of Pneumocystis pneumonia: evaluation of four serologic biomarkers
Esteves, F.; Calé, S. S.; Badura, Robert; de Boer, M.G.; Maltez, F.; Calderón, E. J.; van der Reijden, T. J.; Márquez-Martín, E.; Antunes, FranciscoThe diagnosis of Pneumocystis pneumonia (PCP) relies on microscopic visualization of Pneumocystis jirovecii organisms or DNA detection in pulmonary specimens. This study aimed to assess the usefulness of (1-3)-β-d-glucan (BG), Krebs von den Lungen-6 antigen (KL-6), lactate dehydrogenase (LDH) and S-adenosyl methionine (SAM) as serologic biomarkers in the diagnosis of PCP. Serum levels of BG, KL-6, LDH and SAM w...
HIV-2 integrase polymorphisms and longitudinal genotypic analysis of HIV-2 infe...
Cavaco-Silva, J.; Abecasis, A.; Miranda, A.; Poças, J.; Narciso, J.; Águas, M.; Maltez, F.; Almeida, I.; Germano, I.; Diniz, A.; Gonçalves, M.To characterize the HIV-2 integrase gene polymorphisms and the pathways to resistance of HIV-2 patients failing a raltegravir-containing regimen, we studied 63 integrase strand transfer inhibitors (INSTI)-naïve patients, and 10 heavily pretreated patients exhibiting virological failure while receiving a salvage raltegravir-containing regimen. All patients were infected by HIV-2 group A. 61.4% of the integrase r...
Multiresistent tuberculosis: the third pandemic?
Maltez, F.; Machado, J.; Morgado, A.; Proença, R.The authors describe their recent experience with single and multidrug resistant tuberculo sis, associated with HIV infection. They emphasize particularly, the dimensions and gravity of this problem, for institutions and Public Health.; Os autores descrevem a sua experiência re cente com tuberculose resistente e multirresistente, no contexto da infecção pelo vírus da imunodeficiência humana. Chamam em part...