70 documents found, page 1 of 7
Desafio Duplo: Pericardite Tuberculosa a Condicionar Pericardite Constritiva Aguda
Sobreiros Krowicki, Jéssica; Mateus, Daniela; Lino, Sara; Betkova, Stepanka; Manata, Maria José; Maltez, FernandoA pericardite constritiva, manifesta-se como uma doença rara, que se caracteriza pela perda de distensibilidade do pericárdio, secundária a um processo inflamatório. A tuberculose (TB) é a principal causa de pericardite constritiva nos países de baixo rendimento e nos doentes imunodeprimidos, nomeadamente, com infeção por vírus da imunodeficiência humana (VIH). Os autores relatam o caso de um homem de 24 anos, ...
Residency Training in Infectious Diseases: Assessment and Perception of the Cli...
Ganicho, José; Garrote, Ana Raquel; Manata, Maria José; Maltez, Fernando; Tavares, RaquelIntroduction: The World Health Organization identified 13 critical threats to global health for the coming decade, including infectious disease prevention and antimicrobial resistance. Given the ongoing advancements in scientific evidence, it is imperative to discuss the Infectious Diseases training program. The aim of this study was to characterize and explore the respondents’ perceptions regarding Infectious ...
Preventing Laboratory-Acquired Infection: Literature Review and Case-Based Post...
Póvoas, Diana; Demengeot, Jocelyne; Maltez, FernandoOccupationally acquired cases of the intracellular parasite have been reported, even though there is uncertainty on which infection prevention measures should be implemented in such event. We report a clinical case of laboratory-acquired toxoplasmosis and propose a protocol for post-exposure prophylaxis, given there are no formal guidelines. In this community case study, we describe the management and preventio...
The Microevolutionary Trajectory of Endemic Multidrug-Resistant Tuberculosis St...
Gomes, Pedro; Paixão, Paulo; Maltez, Fernando; Brum, Laura; Phelan, Jody E; Campino, Susana; Clark, Taane G; Viveiros, Miguel; Portugal, IsabelPortugal has one of the highest incidence rates of tuberculosis (TB) in Western Europe and, historically, multidrug-resistant (MDR) cases have been strongly associated with strains pertaining to the endemic Q1 and Lisboa3 clades. Notwithstanding, the contribution of drug resistance-associated allelic configurations in these clades to differing levels of drug resistance and their relationship with drug efficacy ...
The impact of orthopoxvirus vaccination and Mpox infection on cross-protective ...
Crandell, Jameson; Pischel, Lauren; Fang, Zhenhao; Conde, Luciana; Zhong, Yi; Lawres, Lauren; Meira de Asis, Gustavo; Maciel, GabrielaBackground: Cross-reactive immune memory responses to orthopoxviruses in humans remain poorly characterised despite their relevance for vaccine design and outbreak control. We aimed to assess the magnitude, specificity, and durability of cross-reactive immune responses elicited by smallpox vaccines and mpox virus infection. Methods: We did a multicohort observational study involving participants from the USA, B...
Determinants of HIV-1 transmission clusters and transmitted drug resistance in ...
Abrantes, Ricardo; Pimentel, Victor; Sebastião, Cruz; Miranda, Mafalda N. S.; Seabra, Sofia; Silva, Ana Rita; Diniz, António; Ascenção, BiancaIn the EU/EEA, men who have sex with men (MSM) is a priority group for the prevention and control of HIV-1 infection. In Portugal, the 2023 HIV incidence rate was 8.2 per 100,000 inhabitants, with 876 new infections, 41.7% in MSM. We aim to characterize HIV-1 transmission clusters (TC) and transmitted drug resistance (TDR) and its sociodemographic, behavioral, clinical, and viral genomic determinants in MSM new...
Determinants of HIV-1 Transmission Clusters and Transmitted Drug Resistance in ...
Abrantes, Ricardo; Pimentel, Victor; Sebastião, Cruz; Miranda, Mafalda N S; Seabra, Sofia; Silva, Ana Rita; Diniz, António; Ascenção, BiancaIntroduction: In the EU/EEA, men who have sex with men (MSM) is a priority group for the prevention and control of HIV-1 infection. In Portugal, the 2023 HIV incidence rate was 8.2 per 100,000 inhabitants, with 876 new infections, 41.7% in MSM. We aim to characterize HIV-1 transmission clusters (TC) and transmitted drug resistance (TDR) and its sociodemographic, behavioral, clinical, and viral genomic determina...
Addressing Critical Fungal Pathogens Under a One Health Perspective
Sabino, Raquel; Antunes, Francisco; Araújo, Ricardo; Bezerra, Ana Rita; Brandão, João C.; Carneiro, Carla; Carvalho, Agostinho; Carvalho, DinahFungal infections have emerged as a significant public health concern, especially with the increasing incidence of severe mycoses caused by pathogens such as Aspergillus fumigatus, Candida auris, Candida albicans, and Cryptococcus neoformans. These fungi, listed as critical priorities by the World Health Organization, pose a heightened risk due to rising antifungal resistance and their severe impact on immunoco...
Knowledge and HIV‐related stigma among Portuguese healthcare professionals: a c...
Medeiros, Fábio; Méndez‐López, A.; Correia de Abreu, R.; Sarmento e Castro, R.; Maltez, Fernando; Antunes, FranciscoIntroduction: Stigma and discrimination against people living with human immunodeficiency virus (PLHIV) within healthcare settings remain significant barriers to effective care. Stigmatizing attitudes persist among healthcare professionals, potentially undermining care quality. This study aimed to assess HIV-related knowledge and attitudes among healthcare professionals in Portugal, focusing on identifying fact...
Determinants of HIV-1 transmission clusters and transmitted drug resistance in ...
Abrantes, Ricardo; Pimentel, Victor; Sebastião, Cruz; Miranda, Mafalda N. S.; Seabra, Sofia; Silva, Ana Rita; Diniz, António; Ascenção, BiancaIntroduction: In the EU/EEA, men who have sex with men (MSM) is a priority group for the prevention and control of HIV-1 infection. In Portugal, the 2023 HIV incidence rate was 8.2 per 100,000 inhabitants, with 876 new infections, 41.7% in MSM. We aim to characterize HIV-1 transmission clusters (TC) and transmitted drug resistance (TDR) and its sociodemographic, behavioral, clinical, and viral genomic determina...