2 documents found, page 1 of 1
Structural characterization of unusually stable polycyclic ozonides.
Cusati, Raphael Campos; Pereira, Ulisses Alves; Barbosa, Luiz Cláudio de Almeida; Maltha, Célia Regina Alvares; Carneiro, José Walkimar de MesquitaThe single crystal structure of seven tri- and tetracyclic ozonides derived from 8-oxabicycle[3.2.1]oct-6- en-3-ones have been characterized by X-ray diffraction method. Five ozonides (4, 5, 6, 7 and 8) crystallize in the monoclinic crystal system with P21/c space group. Compound 3 crystallize in the unusual centrosymmetric space group R_3m, which represents _0.04% of the total number of structures know. The su...
Induction of G2/M arrest, caspase activation and apoptosis by a-santonin deriva...
Ferreira, José Roberto Oliveira; Cavalcanti, Bruno Coêlho; Costa, Patricia Marçal da; Arantes, Francisco Frederico Perlinson deSesquiterpene lactones (SLs) are natural products with a variety of biological activities. Previously, we demonstrated the cytotoxic effects of three new a-santonin derivatives on different tumor cell lines with low toxic effects upon peripheral human leukocytes. Here, we evaluated the mechanism of action triggered by these derivatives. HL-60 cell cycle determined after 24 h treatment revealed a significant inh...