48 documents found, page 1 of 5
ApoE Mimetic Peptides to Improve the Vicious Cycle of Malnutrition and Enteric ...
Oriá, Reinaldo B.; Freitas, Raul S.; Roque, Cássia R.; Nascimento, José Carlos R; Silva, Ana Paula; Malva, João O.; Guerrant, Richard L.Apolipoprotein E (apoE) mimetic peptides are engineered fragments of the native apoE protein's LDL-receptor binding site that improve the outcomes following a brain injury and intestinal inflammation in a variety of models. The vicious cycle of enteric infections and malnutrition is closely related to environmental-driven enteric dysfunction early in life, and such chronic inflammatory conditions may blunt the ...
The Transition From Undernutrition to Overnutrition Under Adverse Environments ...
Leocádio, Paola Caroline L.; Lopes, Synara C.; Dias, Ronaldo P.; Alvarez-Leite, Jacqueline I.; Guerrant, Richard L.; Malva, João O.; Oriá, Reinaldo B.Nutritional transition is an important public health issue in developing countries, where switch from undernutrition to overnutrition/obesity is rapidly occurring, often within two or three generations. Such transition is related to changes in lifestyle, with people having more access to western high-caloric diets. In developing countries, settings of poverty, poor sanitation and hygiene are still common, where...
Cellular and Molecular Mechanisms Mediating Methylmercury Neurotoxicity and Neu...
Novo, João P.; Martins, Beatriz; Raposo, Ramon S.; Pereira, Frederico C.; Oriá, Reinaldo B; Malva, João O.; Fontes-Ribeiro, CarlosMethylmercury (MeHg) toxicity is a major environmental concern. In the aquatic reservoir, MeHg bioaccumulates along the food chain until it is consumed by riverine populations. There has been much interest in the neurotoxicity of MeHg due to recent environmental disasters. Studies have also addressed the implications of long-term MeHg exposure for humans. The central nervous system is particularly susceptible t...
Editorial: Interplay Between Nutrition, the Intestinal Microbiota and the Immun...
Oriá, Reinaldo B; Empadinhas, Nuno; Malva, João O.Santa Casa da Misericórdia de Lisboa—Mantero Belard Neurosciences Prize 2016 (MB-40-2016), FEDER-CENTRO 2020—CENTRO-01-0145-FEDER-000012 (HealthyAging 2020) and COMPETE and FCT (POCI-01-0145-FEDER- 029221 and UIDB/04539/2020), Pest-C/SAU/UI3282/2013-2014 and CNC.IBILI UID/NEU/04539/2013 with national funds PT2020/COMPETE 2020 and FCT/FUNCAP (POCTI-FEDER- 02/SAICT/2017/31699), Brazilian CAPES-PROCAD (071/2013 # ...
Methylmercury Impact on Adult Neurogenesis: Is the Worst Yet to Come From Recen...
Raposo, Ramon da Silva; Pinto, Daniel Vieira; Moreira, Ricardo; Dias, Ronaldo Pereira; Ribeiro, Carlos Alberto Fontes; Oriá, Reinaldo BarretoWorldwide environmental tragedies of anthropogenic origin causing massive release of metals and other pollutants have been increasing considerably. These pollution outbreaks affect the ecosystems and impact human health. Among those tragedies, recent large-scale environmental disasters in Brazil strongly affected riverside populations, leading to high-risk exposure to methylmercury (MeHg). MeHg is highly neurot...
Methylmercury Interactions With Gut Microbiota and Potential Modulation of Neur...
Pinto, Daniel V.; Raposo, Ramon S.; Matos, Gabriella A.; Alvarez-Leite, Jacqueline I.; Malva, João O.; Oriá, Reinaldo B.Mercury (Hg) is a well-recognized biohazard for the nervous system. Methylmercury (MeHg) is an organic methylated form of Hg, highly toxic to humans, targeting the brain, as MeHg is rapidly absorbed, and easily reaches and crosses the blood-brain barrier (Takahashi et al., 2017). Neurological symptoms may vary from acute motor and visual effects to marked behavioral and psychiatric alterations. At higher neurot...
Effect of hypoproteic and high-fat diets on hippocampal blood-brain barrier per...
Aquino, Cristhyane Costa de; Leitão, Ricardo A.; Alves, Luis Antonio de Oliveira; Coelho-Santos, Vanessa; Guerrant, Richard L.; Ribeiro, Carlos F.Worldwide, millions of people are exposed to dietary imbalance that impacts in health and quality of life. In developing countries, like in Brazil, in poor settings, dietary habits, traditionally hypoproteic, are changing rapidly to western-type high-fat foods. These rapidly changing dietary habits are imposing new challenges to human health and there are many questions in the field that remain to be answered. ...
Development of a Healthy Lifestyle Assessment Toolkit for the General Public
Reis, Flávio; Sá-Moura, Bebiana; Guardado, Diana; Couceiro, Patrícia; Catarino, Luis; Mota-Pinto, Anabela; Veríssimo, Manuel T.; Teixeira, Ana MariaThe prevalence of age-related non-communicable chronic diseases has increased worldwide, being the leading causes of morbidity and death in many world regions, including in Europe. Innovative models and strategies focused on preventive care, including early identification of risk factors underlying disease onset and progression, and proper modification of lifestyle habits and behaviors, might contribute to prom...
What Do Microglia Really Do in Healthy Adult Brain?
Augusto-Oliveira, Marcus; Arrifano, Gabriela P.; Lopes-Araújo, Amanda; Santos-Sacramento, Leticia; Takeda, Priscila Y.; Anthony, Daniel C.Microglia originate from yolk sac-primitive macrophages and auto-proliferate into adulthood without replacement by bone marrow-derived circulating cells. In inflammation, stroke, aging, or infection, microglia have been shown to contribute to brain pathology in both deleterious and beneficial ways, which have been studied extensively. However, less is known about their role in the healthy adult brain. Astrocyte...
Adult Hippocampal Neurogenesis in Different Taxonomic Groups: Possible Function...
Augusto-Oliveira, Marcus; Arrifano, Gabriela P F; Malva, João O.; Crespo-Lopez, Maria ElenaAdult neurogenesis occurs in many species, from fish to mammals, with an apparent reduction in the number of both neurogenic zones and new neurons inserted into established circuits with increasing brain complexity. Although the absolute number of new neurons is high in some species, the ratio of these cells to those already existing in the circuit is low. Continuous replacement/addition plays a role in spatial...