5 documents found, page 1 of 1
Peptidomics Unveils Distinct Acetylation Patterns of Histone and Annexin A1 in ...
Coelho, M; Capela, J; Mendes, VM; Pacheco, J; Fernandes, MS; Amendoeira, I; Jones, JG; Raposo, L; Manadas, BThyroid cancer is a common malignancy of the endocrine system. Nodules are routinely evaluated for malignancy risk by fine needle aspiration biopsy (FNAB), and in cases such as follicular lesions, differential diagnosis between benign and malignant nodules is highly uncertain. Therefore, the discovery of new biomarkers for this disease could be helpful in improving diagnostic accuracy. Thyroid nodule biopsies w...
Proteomics Reveals mRNA Regulation and the Action of Annexins in Thyroid Cancer
Coelho, M; Capela, J; Anjo, SI; Pacheco, J; Fernandes, MS; Amendoeira, I; Jones, JG; Raposo, L; Manadas, BDifferentiated thyroid cancer is the most common malignancy of the endocrine system. Although most thyroid nodules are benign, given the high incidence of thyroid nodules in the population, it is important to understand the differences between benign and malignant thyroid cancer and the molecular alterations associated with malignancy to improve detection and signal potential diagnostic, prognostic, and therape...
Changes in the salivary proteome of beagle dogs after weight loss
Lucena, S; Varela-Coelho, A; Muñoz-Prieto, A; Anjo, SI; Manadas, B; Capela e Silva, Fernando; Lamy, E; Tvarijonaviciute, ABeing overweight or obese represents an important health issue in humans and pets. The aim of this study was to investigate changes in the salivary proteome of overweight beagles after induced weight loss to better understand the physiological changes involved in this process. Five overweight/obese neutered males of pure breed beagles were evaluated. During the 3-mo period of weight loss, each animal received a...
The Potential of Metabolomics in the Diagnosis of Thyroid Cancer
Coelho, M; Raposo, L; Goodfellow, BJ; Atzori, L; Jones, J; Manadas, BThyroid cancer is the most common endocrine system malignancy. However, there is still a lack of reliable and specific markers for the detection and staging of this disease. Fine needle aspiration biopsy is the current gold standard for diagnosis of thyroid cancer, but drawbacks to this technique include indeterminate results or an inability to discriminate different carcinomas, thereby requiring additional sur...
Circulating biomarkers in schizophrenia: a proteomics perspective.
Santa, C; Coelho, JF; Madeira, N; Manadas, B