2 documents found, page 1 of 1
Monoamine oxidase A-dependent ROS formation modulates human cardiomyocyte diffe...
Di Sante, Moises; Antonucci, Salvatore; Pontarollo, Laura; Cappellaro, Ilaria; Segat, Francesca; Deshwal, Soni; Greotti, Elisa; Grilo, Luís F.During embryonic development, cardiomyocytes undergo differentiation and maturation, processes that are tightly regulated by tissue-specific signaling cascades. Although redox signaling pathways involved in cardiomyogenesis are established, the exact sources responsible for reactive oxygen species (ROS) formation remain elusive. The present study investigates whether ROS produced by the mitochondrial flavoenzym...
Neuronal cell-based high-throughput screen for enhancers of mitochondrial funct...
Naia, Luana Carvalho; Pinho, Catarina M.; Dentoni, Giacomo; Liu, Jianping; Leal, Nuno Santos; Ferreira, Duarte M. S.; Schreiner, BernadetteBackground: Mitochondrial dysfunction is a common feature of aging, neurodegeneration, and metabolic diseases. Hence, mitotherapeutics may be valuable disease modifiers for a large number of conditions. In this study, we have set up a large-scale screening platform for mitochondrial-based modulators with promising therapeutic potential. Results: Using differentiated human neuroblastoma cells, we screened 1200 F...