5 documents found, page 1 of 1
γδ-T cells promote IFN-γ–dependent Plasmodium pathogenesis upon liver-stage inf...
Ribot, Julie C.; Neres, Rita; Zuzarte-Luís, Vanessa; Gomes, Anita Quintal; Mancio-Silva, Liliana; Mensurado, Sofia; Pinto-Neves, DanielCerebral malaria (CM) is a major cause of death due to Plasmodium infection. Both parasite and host factors contribute to the onset of CM, but the precise cellular and molecular mechanisms that contribute to its pathogenesis remain poorly characterized. Unlike conventional αβ-T cells, previous studies on murine γδ-T cells failed to identify a nonredundant role for this T cell subset in experimental cerebral mal...
γδ-T cells promote IFN-γ–dependent Plasmodium pathogenesis upon liver-stage inf...
Ribot, Julie; Neres, Rita; Zuzarte-Luis, Vanessa; Gomes, Anita Q.; Mancio-Silva, Liliana; Mensurado, Sofia; Neves, Daniel; Monteiro Dos Santos, MiguelCerebral malaria (CM) is a major cause of death due to Plasmodium infection. Both parasite and host factors contribute to the onset of CM, but the precise cellular and molecular mechanisms that contribute to its pathogenesis remain poorly characterized. Unlike conventional αβ-T cells, previous studies on murine γδ-T cells failed to identify a nonredundant role for this T cell subset in experimental cerebral mal...
Targeting liver stage malaria with metformin
Vera, Iset; Ruivo, Margarida; LEMOS ROCHA, Leonardo Filipe; Marques, Sofia; Bhatia, Sangeeta N.; Mota, Maria M.; Mancio-Silva, LilianaDespite an unprecedented 2 decades of success, the combat against malaria - the mosquito-transmitted disease caused by Plasmodium parasites - is no longer progressing. Efforts toward eradication are threatened by the lack of an effective vaccine and a rise in antiparasite drug resistance. Alternative approaches are urgently needed. Repurposing of available, approved drugs with distinct modes of action are being...
Host AMPK Is a modulator of Plasmodium liver infection
Ruivo, Margarida; Vera, Iset; Sales Dias, Joana; Meireles, Patricia; Gural, Nil; Bhatia, Sangeeta N.; Mota, Maria M.; Mancio-Silva, LilianaManipulation of the master regulator of energy homeostasis AMP-activated protein kinase (AMPK) activity is a strategy used by many intracellular pathogens for successful replication. Infection by most pathogens leads to an activation of host AMPK activity due to the energetic demands placed on the infected cell. Here, we demonstrate that the opposite is observed in cells infected with rodent malaria parasites. ...
A mediator for malaria stickiness in A versus O blood
Mancio-Silva, Liliana; Mota, Maria M.Malaria is thought to have shaped the worldwide distribution of human ABO blood but the underlying molecular details of this process have only recently started to be revealed. A new study provides insights on how malaria parasites interact with ABO blood group sugars, mediating rosetting events that cause severe disease.