3 documents found, page 1 of 1
Resection of Colorectal Liver Metastases After Second-Line Chemotherapy: Is It ...
Adam, R; Yi, B; Innominato, PF; Barroso, E; Laurent, C; Giuliante, F; Capussotti, L; Lapointe, R; Regimbeau, JM; Lopez-Ben, S; Isoniemi, H; Hubert, CPURPOSE: Patient outcome after resection of colorectal liver metastases (CLM) following second-line preoperative chemotherapy (PCT) performed for insufficient response or toxicity of the first-line, is little known and has here been compared to the outcome following first-line. PATIENTS AND METHODS: From January 2005 to June 2013, 5624 and 791 consecutive patients of a prospective international cohort received ...
Fatigue and weight loss predict survival on circadian chemotherapy for metastat...
Innominato, PF; Giacchetti, S; Moreau, T; Bjarnason, GA; Smaaland, R; Focan, C; Garufi, C; Iacobelli, S; Tampellini, M; Tumolo, S; Carvalho, CBACKGROUND:Chemotherapy-induced neutropenia has been associated with prolonged survival selectively in patients on a conventional schedule (combined 5-fluorouracil, leucovorin, and oxaliplatin [FOLFOX2]) but not on a chronomodulated schedule of the same drugs administered at specific circadian times (chronoFLO4). The authors hypothesized that the early occurrence of chemotherapy-induced symptoms correlated with...
Prediction of survival by neutropenia according to delivery schedule of oxalipl...
Innominato, PF; Giacchetti, S; Moreau, T; Carvalho, C, et al.Circadian clocks control cellular proliferation and drug metabolism over the 24 h. However, circadian chronomodulated chemotherapy with 5-fluorouracil, leucovorin, and oxaliplatin (chronoFLO4) offered no survival benefit as compared with the non-time-stipulated FOLFOX2, in an international randomized trial involving patients with previously untreated metastatic colorectal cancer (EORTC 05963). The authors hypot...