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Pineal Gland ADC Values in Children Aged 0 to 4 Years: Normative Data and Usefu...

Freire, Inês; Falsitta, Lydia Viviana; Sharma, Chetan; Löbel, Ulrike; Sudhakar, Sniya; Biswas, Asthik; Cooper, Jessica; Mankad, Kshitij; Hilal, Kiran

Purpose: Normative ADC values of the pineal gland in young children are currently lacking, however, these are potentially useful in the differential diagnosis of pineal involvement in trilateral retinoblastoma, which is challenging when the size of the tumor is less than 10-15 mm. The main objective of this study was to establish ADC reference values of the normal pineal gland in a large cohort of children betw...


Natural history of familial cerebral cavernous malformation syndrome in childre...

Geraldo, Ana Filipa; Alves, Cesar Augusto P. F.; Luis, Aysha; Tortora, Domenico; Guimarães, Joana; Abreu, Daisy; Reimão, Sofia; Pavanello, Marco

Purpose: There is limited data concerning neuroimaging findings and longitudinal evaluation of familial cerebral cavernous malformations (FCCM) in children. Our aim was to study the natural history of pediatric FCCM, with an emphasis on symptomatic hemorrhagic events and associated clinical and imaging risk factors. Methods: We retrospectively reviewed all children diagnosed with FCCM in four tertiary pediatric...


Spinal involvement in pediatric familial cavernous malformation syndrome

Geraldo, Ana Filipa; Luis, Aysha; Alves, Cesar Augusto P. F.; Tortora, Domenico; Guimarães, Joana; Reimão, Sofia; Pavanello, Marco; de Marco, Patrizia

Purpose: The aim of the study was to assess the prevalence and characteristics of spinal cord cavernous malformations (SCCM) and intraosseous spinal vascular malformations (ISVM) in a pediatric familial cerebral cavernous malformation (FCCM) cohort and evaluate clinico-radiological differences between children with (SCCM +) and without (SCCM-) SCCM. Methods: All patients with a pediatric diagnosis of FCCM evalu...


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