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EPICE cohort: two-year neurodevelopmental outcomes after very preterm birth

Draper, ES; Zeitlin, J; Manktelow, BN; Piedvache, A; Cuttini, M; Edstedt Bonamy, AK; Maier, R; Koopman-Esseboom, C; Gadzinowski, J; Boerch, K

Objective: To determine whether the variation in neurodevelopmental disability rates between populations persists after adjustment for demographic, maternal and infant characteristics for an international very preterm (VPT) birth cohort using a standardised approach to neurodevelopmental assessment at 2 years of age. Design: Prospective standardised cohort study. Setting: 15 regions in 10 European countries. Pa...


Variability in Very Preterm Stillbirth and In-Hospital Mortality Across Europe

Draper, ES; Manktelow, BN; Cuttini, M; Maier, RF; Fenton, AC; Van Reempts, P; Bonamy, AK; Mazela, J; Bᴓrch, K; Koopman-Esseboom, C; Varendi, H

BACKGROUND AND OBJECTIVE: Stillbirth and in-hospital mortality rates associated with very preterm births (VPT) vary widely across Europe. International comparisons are complicated by a lack of standardized data collection and differences in definitions, registration, and reporting. This study aims to determine what proportion of the variation in stillbirth and in-hospital VPT mortality rates persists after adju...


Variability in the management and outcomes of extremely preterm births across f...

Smith, LK; Blondel, B; Van Reempts, P; Draper, ES; Manktelow, BN; Barros, H; Cuttini, M; Zeitlin, J

Objective: To explore international variations in the management and survival of extremely low gestational age and birthweight births. Design Area-based prospective cohort of births: Setting 12 regions across Belgium, France, Italy, Portugal and the UK. Participants: 1449 live births and fetal deaths between 22+0 and 25+6 weeks gestation born in 2011–2012. Main outcome measures: Percentage of births; recorded l...


Stillbirths: Rates, risk factors, and acceleration towards 2030

Lawn, JE; Blencowe, H; Waiswa, P; Amouzou, A; Mathers, C; Hogan, D; Flenady, V; Frøen, JF; Qureshi, ZU; Calderwood, C; Shiekh, S; Jassir, FB; You, D

An estimated 2·6 million third trimester stillbirths occurred in 2015 (uncertainty range 2·4-3·0 million). The number of stillbirths has reduced more slowly than has maternal mortality or mortality in children younger than 5 years, which were explicitly targeted in the Millennium Development Goals. The Every Newborn Action Plan has the target of 12 or fewer stillbirths per 1000 births in every country by 2030. ...


Use of evidence based practices to improve survival without severe morbidity fo...

Zeitlin, J; Manktelow, BN; Piedvache, A; Cuttini, M; Boyle, E; van Heijst, A; Gadzinowski, J; van Reempts, P; Huusom, L; Weber, T; Schmidt, S; Barros, H

Objectives To evaluate the implementation of four high evidence practices for the care of very preterm infants to assess their use and impact in routine clinical practice and whether they constitute a driver for reducing mortality and neonatal morbidity. Design Prospective multinational population based observational study. Setting 19 regions from 11 European countries covering 850 000 annual births participati...


Authors' reply to Page and Rafi

Zeitlin, J; Manktelow, BN; Piedvache, A; Cuttini, M; Boyle, E; Van Heijst, A; Gadzinowski, J; Van Reempts, P; Huusom, L; Weber, T; Schmidt, S; Barros, H


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