4 documents found, page 1 of 1
Therapeutic role of deep eutectic solvents based on menthol and saturated fatty...
Silva, Joana M.; Pereira, Carolina Jesus Vieira; Mano, Francisca; Silva, Eduardo; Castro, Vânia Isabel Baptista; Sá-Nogueira, Isabel; Reis, R. L.The breakthroughs achieved in green solvents promote the emergence of therapeutic deep eutectic solvents (THEDES), which possess intriguing possible applications in the biomedical field. Herein, the main aim was to unravel the biomedical potential of hydrophobic THEDES based in menthol and saturated fatty acids with different chain lengths (e.g., stearic acid (SA), myristic acid (MA), and lauric acid (LA)). Our...
Production of electrospun fast-dissolving drug delivery systems with therapeuti...
Mano, Francisca; Martins, Marta; Nogueira, Isabel Sá; Barreiros, Susana; Borges, João Paulo; Reis, R. L.; Duarte, Ana Rita C.; Paiva, AlexandreFast-dissolving delivery systems (FDDS) have received increasing attention in the last years. Oral drug delivery is still the preferred route for the administration of pharmaceutical ingredients. Nevertheless, some patients, e.g. children or elderly people, have difficulties in swallowing solid tablets. In this work, gelatin membranes were produced by electrospinning, containing an encapsulated therapeutic deep...
Dissolution enhancement of active pharmaceutical ingredients by therapeutic dee...
Aroso, Ivo Manuel Ascensão; Silva, João C.; Mano, Francisca; Ferreira, Ana S. D.; Dionísio, Madalena; Nogueira, Isabel Sá; Barreiros, SusanaA therapeutic deep eutectic system (THEDES) is here defined as a deep eutectic solvent (DES) having an active pharmaceutical ingredient (API) as one of the components. In this work, THEDESs are proposed as enhanced transporters and delivery vehicles for bioactive molecules. THEDESs based on choline chloride (ChCl) or menthol conjugated with three different APIs, namely acetylsalicylic acid (AA), benzoic acid (B...
Production of Poly(vinyl alcohol) (PVA) fibers with encapsulated natural deep e...
Mano, Francisca; Aroso, Ivo Manuel Ascensão; Barreiros, Susana; Borges, João Paulo; Reis, R. L.; Duarte, Ana Rita C.; Paiva, AlexandreFunctionalized electrospun fibers are of great interest for biomedical applications such as in the design of drug delivery systems. Nevertheless, in some cases the molecules of interest have poor solubility in water or have high melting temperatures. These drawbacks can be overcome using deep eutectic solvents. In this work, poly(vinyl alcohol) (PVA), a common biodegradable biopolymer, was used to produce new f...