5 documents found, page 1 of 1
X-linked Hypophosphatemic Rickets: a New Mutation
Maio, P; Mano, L; Rocha, S; Baeta Baptista, R; Francisco, T; Sousa, H; Parente Freixo, J; Abranches, MPhosphopenic rickets may be caused by mutations in the PHEX gene (phosphate regulating endopeptidase homolog X-linked). Presently, more than 500 mutations in the PHEX gene have been found to cause hypophosphatemic rickets. The authors report a clinical case of a 4-year-old girl with unremarkable family history, who presented with failure to thrive and bowing of the legs. Laboratory tests showed hypophosphatemia...
Ciliopatias – Experiência de uma Unidade de Nefrologia Pediátrica de um Hospita...
Maio, P; Rocha, S; Mano, L; Francisco, T; Santos, R; Serrão, AP; Abranches, MIntrodução: As ciliopatias constituem um grupo de doenças associadas a mutações genéticas que condicionam alterações na estrutura e função dos cílios. A disfunção ciliar pode manifestar-se com doença renal, degeneração retiniana e anomalias cerebrais. Outras manifestações menos frequentes são a doença fibroquística congénita do fígado, diabetes, obesidade e displasia óssea. Objetivo: Caracterizar os casos de ci...
Influenza B-Associated Atypical Hemolytic Uremic Syndrome
Mano, L; Rocha, S; Maio, P; Francisco, T; Pereira, G; Gomes, S; Santos, R; Serrão, AP; Abranches, MIntroduction: Influenza A infections have been described to cause secondary hemolytic uremic syndrome and to trigger atypical hemolytic uremic syndrome (aHUS) in individuals with an underlying genetic complement dysregulation. To date, Influenza B has only been reported to trigger aHUS in 2 patients. In 61% of aHUS cases, mutations are found in H, B and I factors, membrane cofactor protein (MCP), C3 and thrombo...
Everolimus no Tratamento da Esclerose Tuberosa
Rocha, S; Mano, L; Maio, P; Francisco, T; Santos, R; Pacheco, L; Serrão, AP; Abranches, MIntrodução: A esclerose tuberosa (ET) é um distúrbio genético que atinge vários processos celulares, resultando numa variedade de lesões hamartomatosas que podem afetar qualquer órgão. O envolvimento renal constitui a segunda causa de morte prematura, sendo os angiomiolipomas (AML) a alteração mais frequente (70-80% dos doentes) e cuja sintomatologia está diretamente relacionada com as dimensões dos AML. Descri...
Hypophosphatemic Rickets: A New Mutation
Maio, P; Rocha, S; Mano, L; Francisco, T; Sousa, H; Freixo, J; Abranches, MIntroduction: Phosphopenic rickets is characterized by hypophosphatemia with hyperphosphaturia, normal calcemia and normal or mildly elevated PTH. This pathology may be caused by mutations in PHEX gene (phosphate regulating endopeptidase homolog X-linked). We present a clinical report of a girl with phosphopenic rickets, as consequence of a new mutation of PHEX gene. Clinical Case: We present a 4-year-old femal...