6 documents found, page 1 of 1
The Initial Journey of Patients with Metastatic Pancreatic Cancer (PaCTO Projec...
Barros, AG; Mansinho, H; Couto, N; Teixeira, MR; Tonin, FS; Francisco, R; Duarte-Ramos, FIntroduction: We aimed to characterize the initial healthcare journey of metastatic pancreatic ductal adenocarcinoma (mPDAC) patients in Portugal, including healthcare provision and factors affecting therapeutic decisions, namely BRCA mutations testing. Methods: This is a descriptive cross-sectional, web-based survey using a convenience sampling approach. Portuguese oncologists and pathologists that routinely w...
Recommendations for Mutational Analysis in Gastrointestinal Stromal Tumors (GISTs)
Lopes, J M; Soares, M; Gouveia, A M; Barroso, S; Cravo, M; Mansinho, H; Penedo, J; Sá, A; Santos, L L; Teixeira, J AGIST Portuguese Working Group – Condeixa ProposalThe authors outline recommendations for the mutational analysis of GISTs unanimously approved by a multidisciplinary group on July 20th, 2062. The mutational status of KIT and PDGFRA allows identifying therapeutic targets to tyrosine kinase inhibitors (TKIs), and therefore, the safe clinical practice in the biotherapy decisions for patients with GISTs should incl...
Recomendações para Análise Mutacional em Tumores do Estroma Gastrointestinal (G...
Lopes, JM; Soares, M; Gouveia, AM; Barroso, S; Cravo, M; Mansinho, H; Penedo, L; Sá, A; Santos, LL; Teixeira, JAThe authors outline recommendations for the mutational analysis of GISTs unanimously approved by a multidisciplinary group on July 20th, 2012. The mutational status of KIT and PDGFRA allows identifying therapeutic targets to tyrosine kinase inhibitors (TKIs), and therefore, the safe clinical practice in the biotherapy decisions for patients with GISTs should include the analysis of the mutational status. The mu...
Recomendações para Análise Mutacional em Tumores do Estroma Gastrointestinal (G...
Lopes, JM; Soares, M; Gouveia, AM; Barroso, S; Cravo, M; Mansinho, H; Penedo, J; Sá, A; Santos, LL; Teixeira, JAOs autores apresentam as recomendações para a análise mutacional de GISTs, aprovadas por unanimidade por um grupo multidisciplinar em 20 de Julho de 2012. O estado mutacional de genes como o KIT e o PDGFRA permite identificar alvos terapêuticos para inibidores da tirosinacínase (ITKs) e, por isso, a boa prática clínica nas decisões bioterapêuticas de doentes com GISTs deve incluir a análise do estado mutacional...
The rare metastasis of osteosarcoma of a long bone associated with von Reckling...
Ferreira, M M; Mansinho, H; Fernandes, A; Pereira, F S; Assis e Santos, J AWe report a case of femoral osteosarcoma with brain metastases in a female patient with longstanding von Recklinghausen disease. Osteosarcoma of a long bone has not yet, to our best knowledge, been reported in association with type I Neurofibromatosis. Central nervous system metastases occur very rarely in osteosarcoma.; We report a case of femoral osteosarcoma with brain metastases in a female patient with lon...
Clear cell hepatocellular carcinoma.
Mansinho, H; Ferreira, M; Fernandes, A; Chaves, P; Assis e Santos, .A case of a 62 year old white patient with mild dyspeptic symptoms and nodular hepatomegaly is presented. The histologic examination of a liver biopsy revealed a hepatocellular carcinoma clear cell variant. There were no signs of chronic hepatic failure. The disease showed an indolent clinical behaviour, thus the beginning of chemotherapy was delayed until clinical deterioration was obvious. Clinical improvemen...