3 documents found, page 1 of 1
Kaposi’s Sarcoma: Demographic and Clinical Features, Histopathology, Treatment,...
Pereira Amaral, Inês; Soares, Ivânia; Pupo Correia, Madalena; Tribolet Abreu, Inês; Monteiro, Filipe; Antunes, Joana; Manso, Nuno; de Vasconcelos, PedroIntroduction: Kaposi’s sarcoma (KS) is a rare angioproliferative neoplasm associated with human herpesvirus 8 infection, presenting as four subtypes: classic, endemic, iatrogenic, and epidemic. While well documented globally, comprehensive data on KS in Portugal remain scarce. The aim of this retrospective study was to provide a detailed analysis of KS cases diagnosed at Hospital Santa Maria, in Lisbon, between...
A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic ...
Fonseca-Gomes, João; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Inteiro-Oliveira, Sara; Vaz, Sandra H.; Alemãn-Serrano, NunoIn Alzheimer's disease (AD), amyloid β (Aβ)-triggered cleavage of TrkB-FL impairs brain-derived neurotrophic factor (BDNF) signaling, thereby compromising neuronal survival, differentiation, and synaptic transmission and plasticity. Using cerebrospinal fluid and postmortem human brain samples, we show that TrkB-FL cleavage occurs from the early stages of the disease and increases as a function of pathology seve...
Computerized tomography guided percutaneous procedures
Manso, Nuno; Oliveira, Carlos; Borrega, Pedro; Fernandes, Francelina; Saldanha, Tiago; Martins, Cristina; Sanches, JoséWe review the main indications for computerized tomography (CI) guided percutaneous procedures and describe some of the techniques involved. The authors also analyse the main applications of CT guided diagnostic and therapeutic proceedures of specific organs and sites, some of which are illustrated with iconography from our hospital. The diagnostic sensitivity and specificity are looked at, as well as the ther...