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Functionalized chitosan derivatives as nonviral vectors: Physicochemical proper...

Santos, J; Moreno, PM; Mansur, A; Leiro, V; Mansur, H; Pêgo, AP

Cationic polymers have recently attracted attention due to their proven potential for nonviral gene delivery. In this study, we report novel biocompatible nanocomplexes produced using chemically functionalized N,N,N-trimethyl chitosan (TMC) with different N-acyl chain lengths (C 5 -C 18 ) associated with single-stranded oligonucleotides. The TMC derivatives were synthesized by covalent coupling reactions of qua...

Date: 2015   |   Origin: Repositório Aberto da Universidade do Porto
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