3 documents found, page 1 of 1
Antibacterial effects of novel quaternary ammonium and phosphonium salts agains...
Nunes, B; Cagide, F; Anabela Borges; Borges, F; Simoes, MAim This study investigates the mechanisms of action of a promising series of previously synthesized quaternary ammonium (QASs) and phosphonium (QPSs) salts, which have shown potent activity against Staphylococcus aureus, including methicillin-resistant strains (MRSA).Methods and results The effects of QASs and QPSs on S. aureus surface charge, total surface hydrophobicity, intracellular potassium release, memb...
Efficacy of Novel Quaternary Ammonium and Phosphonium Salts Differing in Cation...
Nunes, B; Cagide, F; Fernandes, C; Anabela Borges; Fernanda Borges; Simoes, M; Simões MAntibacterial resistance poses a critical public health threat, challenging the prevention and treatment of bacterial infections. The search for innovative antibacterial agents has spurred significant interest in quaternary heteronium salts (QHSs), such as quaternary ammonium and phosphonium compounds as potential candidates. In this study, a library of 49 structurally related QHSs was synthesized, varying the ...
Phytochemicals and quaternary phosphonium ionic liquids: Connecting the dots to...
Chavarria, D; Anabela Borges; Benfeito, S; Sequeira, L; Ribeiro, M; Oliveira, C; Borges, F; Simões, M; Cagide, F; Simões MIntroduction: The infections by multidrug-resistant bacteria are a growing threat to human health, and the efficacy of the available antibiotics is gradually decreasing. As such, new antibiotic classes are urgently needed. Objectives: This study aims to evaluate the antimicrobial activity, safety and mechanism of action of phytochemical-based triphenylphosphonium (TPP') conjugates. Methods: A library of phytoch...