13 documents found, page 1 of 2
Communicating and disseminating One Health: successes of the One Health Europea...
Taylor, Emma; Artursson, Karin; Busani, Luca; Callegari, Arnaud; Cantlay, Jennifer; Caniça, Manuela; Campling, Elaine; Gavier-Widén, DoloresThe application of a One Health approach recognizes that human health, animal health, plant health and ecosystem health are intrinsically connected. Tackling complex challenges associated with foodborne zoonoses, antimicrobial resistance, and emerging threats is imperative. Therefore, the One Health European Joint Programme was established within the European Union research programme Horizon 2020. The One Healt...
Developing human biomonitoring as a 21st century toolbox within the European Ex...
Jeddi, Maryam Zare; Hopf, Nancy B.; Louro, Henriqueta; Viegas, Susana; Galea, Karen S.; Pasanen-Kase, Robert; Santonen, Tiina; Mustieles, VicenteHuman biomonitoring (HBM) is a crucial approach for exposure assessment, as emphasised in the European Commission’s Chemicals Strategy for Sustainability (CSS). HBM can help to improve chemical policies in five major key areas: (1) assessing internal and aggregate exposure in different target populations; 2) assessing exposure to chemicals across life stages; (3) assessing combined exposure to multiple chemical...
Developing human biomonitoring as a 21st century toolbox within the European ex...
Zare Jeddi, Maryam; Hopf, Nancy B.; Louro, Henriqueta; Viegas, Susana; Galea, Karen S.; Pasanen-Kase, Robert; Santonen, Tiina; Mustieles, VicenteHuman biomonitoring (HBM) is a crucial approach for exposure assessment, as emphasised in the European Commission’s Chemicals Strategy for Sustainability (CSS). HBM can help to improve chemical policies in five major key areas: (1) assessing internal and aggregate exposure in different target populations; 2) assessing exposure to chemicals across life stages; (3) assessing combined exposure to multiple chemical...
Developing human biomonitoring as a 21st century toolbox within the European ex...
Zare Jeddi, Maryam; Hopf, Nancy B.; Louro, Henriqueta; Viegas, Susana; Galea, Karen S.; Pasanen-Kase, Robert; Santonen, Tiina; Mustieles, VicenteHuman biomonitoring (HBM) is a crucial approach for exposure assessment, as emphasised in the European Commission's Chemicals Strategy for Sustainability (CSS). HBM can help to improve chemical policies in five major key areas: (1) assessing internal and aggregate exposure in different target populations; 2) assessing exposure to chemicals across life stages; (3) assessing combined exposure to multiple chemical...
Risk-benefit in food safety and nutrition - outcome of the 2019 Parma Summer Sc...
Verhagen, Hans; Alonso-Andicoberry, Cristina; Assunção, Ricardo; Cavaliere, Francesca; Eneroth, Hanna; Hoekstra, Jeljer; Koulouris, StylianosRisk-benefit assessment is the comparison of the risk of a situation to its related benefits, i.e. a comparison of scenarios estimating the overall health impact. The risk-benefit analysis paradigm mirrors the classical risk analysis one: risk-benefit assessment goes hand-in-hand with risk-benefit management and risk-benefit communication. The various health effects associated with food consumption, together wi...
Serum amyloid P component is an essential element of resistance against Aspergi...
Doni, Andrea; Parente, Raffaella; Laface, Ilaria; Magrini, Elena; Cunha, Cristina; Colombo, Federico Simone; Lacerda, João; Campos, AntónioSerum amyloid P component (SAP, also known as Pentraxin 2; APCS gene) is a component of the humoral arm of innate immunity involved in resistance to bacterial infection and regulation of tissue remodeling. Here we investigate the role of SAP in antifungal resistance. Apcs-/- mice show enhanced susceptibility to A. fumigatus infection. Murine and human SAP bound conidia, activate the complement cascade and enhan...
Antagonistic inflammatory phenotypes dictate tumor fate and response to immune ...
Bonavita, Eduardo; Bromley, Christian P.; Jonsson, Gustav; Pelly, Victoria S.; Sahoo, Sudhakar; Walwyn-Brown, Katherine; Mensurado, Sofia; Moeini, AgrinInflammation can support or restrain cancer progression and the response to therapy. Here, we searched for primary regulators of cancer-inhibitory inflammation through deep profiling of inflammatory tumor microenvironments (TMEs) linked to immune-dependent control in mice. We found that early intratumoral accumulation of interferon gamma (IFN-γ)-producing natural killer (NK) cells induced a profound remodeling ...
The Two Faces of Tumor-Associated Macrophages and Their Clinical Significance i...
Pinto, Marta L.; Rios, Elisabete; Durães, Cecília; Ribeiro, Ricardo; Machado, José C.; Mantovani, Alberto; Barbosa, Mario A.; Carneiro, FátimaMacrophages are one of the immune populations frequently found in colorectal tumors and high macrophage infiltration has been associated with both better and worst prognosis. Importantly, according to microenvironment stimuli, macrophages may adopt different polarization profiles, specifically the pro-inflammatory or M1 and the anti-inflammatory or M2, which display distinct functions. Therefore, concomitantly ...
The two faces of tumor-associated macrophages and their clinical significance i...
Pinto, Marta L.; Rios, Elisabete; Durães, Cecília; Ribeiro, Ricardo; Machado, José C.; Mantovani, Alberto; Barbosa, Mário A.; Carneiro, FatimaMacrophages are one of the immune populations frequently found in colorectal tumors and high macrophage infiltration has been associated with both better and worst prognosis. Importantly, according to microenvironment stimuli, macrophages may adopt different polarization profiles, specifically the pro-inflammatory or M1 and the anti-inflammatory or M2, which display distinct functions. Therefore, concomitantly ...
Guidelines for the use of flow cytometry and cell sorting in immunological stud...
Cossarizza, Andrea; Chang, Hyun‐Dong; Radbruch, Andreas; Acs, Andreas; Adam, Dieter; Adam‐Klages, Sabine; Agace, William W.; Aghaeepour, NimaThese guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community. They provide the theory and key practical aspects of flow cytometry enabling immunologists to avoid the common errors that often undermine immunological data. Notably, there are comprehensive sections of all major immune cell types with helpful Tables detailing phenotypes in murine and human...