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Optimized in-solution enrichment over a million ancient human SNPs

Davidson, Roberta; Roca-Rada, Xavier; Ravinshakar, Shyamsundar; Taufik, Leonard; Haarkötter, Christian; Collen, Evelyn; Williams, Matthew P.

Background In-solution hybridization enrichment of genetic markers is a method of choice in paleogenomic studies, where the DNA of interest is generally heavily fragmented and contaminated with environmental DNA, and where the retrieval of genetic data comparable between individuals is challenging. Here, we benchmark the commercial “Twist Ancient DNA” reagent from Twist Biosciences using sequencing libraries fr...

Date: 2025   |   Origin: Repositório Científico da Universidade de Évora
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