3 documents found, page 1 of 1
COVID Health Structure Index: The Vulnerability of Brazilian Microregions
Ferraz, Diogo [UNESP]; Mariano, Enzo Barberio [UNESP]; Manzine, Patricia Regina; Moralles, Herick Fernando; Morceiro, Paulo CésarMade available in DSpace on 2021-06-25T11:15:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; Many developing countries have highly unequal health systems across their regions. The pandemic of COVID-19 brought an additional challenge, as hospital structures equipped with doctors, intensive care units and respirators are not available to a sufficient extent in all regions. Using Data Envelopment ...
Evaluation of ADAM10 levels and activity in different biological media
Peron, Rafaela; Vatanabe, Izabela Pereira; Manzine, Patricia Regina; Grigoli, Marina Mantellatto; Cominetti, Márcia ReginaAlzheimer's disease (AD) affects millions of people worldwide and results from two major pathological hallmarks, neurofibrillary tangles and senile plaques. The latter are derived from the cleavage of the amyloid precursor protein (APP) by the amyloidogenic pathway, which is avoided by the a-secretase ADAM10. This study aimed to evaluate ADAM10 levels and activity in different biological media of individuals w...
ADAM10 como biomarcador para a doença de Alzheimer
Manzine, Patricia ReginaFinanciadora de Estudos e Projetos; Alzheimer's disease (AD) is the most common cause of dementia in people over 65 years. Platelet studies with ADAM10 have shown to decrease its expression in AD patients. The association between cognitive testing and molecular biomarkers such as levels of platelet ADAM10 protein can be important tools for the accurate and early diagnosis of AD. The aim of this research was to ...