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Expression of aldehyde dehydrogenase after neoadjuvant chemotherapy is associat...

OBJECTIVE: To analyze the expression of hypoxia-inducible factors (hypoxia-inducible factor 1A and hypoxia-inducible factor 2A) and aldehyde dehydrogenase proteins in patients with locally advanced breast carcinoma who were subjected to neoadjuvant chemotherapy. METHODS: We included 90 patients with histologically confirmed stage II and III breast carcinoma who were treated with neoadjuvant chemotherapy between...

Expression of hypoxia-inducible factor 1-'alfa' and vascular endothelial growth...

Expression of Hypoxia-inducible factor 1-α and Vascular endothelial growth...

BACKGROUND: Locally advanced breast cancers are more prevalent in underdeveloped countries. Targeted therapy has been improved to identify hallmarks that are specific to these subtypes of tumors. OBJECTIVES: We aimed to prospectively assess the expression of Hypoxia inducible factor-1 α and vascular endothelial growth factor-C in locally advanced breast cancer patients. METHODS: Thirty women underwent inci...

Impacto prognóstico da recorrência local em pacientes com câncer inicial de mam...

Tumor-infiltrating CD4+ T lymphocytes in early breast cancer reflect lymph node...

BACKGROUND: The role of immune system in the pathogenesis and progression of breast cancer is a subject of controversy, and this stimulated us to investigate the association of the immunophenotype of tumor-infiltrating lymphocytes in early breast cancer with the spread of tumor cells to axillary lymph nodes. METHODS: Tumor samples from 23 patients with early breast cancer from the Department of Gynecology and O...

Fibromatosis of the male breast: a case report with immunohistochemistry study ...