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Simvastatin attenuates neutrophil recruitment in one-lung ventilation model in ...

Leite,Camila Ferreira; Marangoni,Fábio André; Camargo,Enilton Aparecido; Braga,Angélica de Fátima de Assunção; Toro,Ivan Felizardo Contrera

PURPOSE: To investigate the anti-inflammatory effects of simvastatin in rats undergoing one-lung ventilation (OLV) followed by lung re-expansion. METHODS: Male Wistar rats (n=30) were submitted to 1-h OLV followed by 1-h lung re-expansion. Treated group received simvastatin (40 mg/kg for 21 days) previous to OLV protocol. Control group received no treatment or surgical/ventilation interventions. Measurements of...

Date: 2013   |   Origin: Oasisbr
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