11 documents found, page 1 of 2
Gadoteric acid and gadolinium exposure – what is the impact on kidney gene expr...
Coimbra, Carla; Rocha, Susana; Viana, Sofia D.; Rebelo, Rute; Valente, Maria João; Catarino, Cristina; Belo, Luís; Bronze-da-Rocha, Elsa; Reis, FlávioBackground: The nephrotoxicity of gadolinium [Gd (III)] has been reported, raising concerns about the safety of gadolinium-based contrast agents (GBCA). Gd (III) exposure, in renal tubular cells (HK-2), causes apoptosis, and leads to upregulation of genes related to lipogenesis/lipolysis and to signaling pathways related to inflammation/hypoxia [1].Gadoteric acid (Gd-DOTA), a macrocyclic GBCA, appears to be one...
Blueberry Counteracts Prediabetes in a Hypercaloric Diet-Induced Rat Model and ...
Nunes, Sara; Viana, Sofia D.; Preguiça, Inês; Alves, André; Fernandes, Rosa; Teodoro, João S.; Matos, Patrícia; Figueirinha, Artur; Salgueiro, LígiaThe paramount importance of a healthy diet in the prevention of type 2 diabetes is now well recognized. Blueberries (BBs) have been described as attractive functional fruits for this purpose. This study aimed to elucidate the cellular and molecular mechanisms pertaining to the protective impact of blueberry juice (BJ) on prediabetes. Using a hypercaloric diet-induced prediabetic rat model, we evaluated the effe...
Acute MDPV Binge Paradigm on Mice Emotional Behavior and Glial Signature
Campeão, Mafalda; Fernandes, Luciana; Pita, Inês R.; Lemos, Cristina; Ali, Syed F.; Carvalho, Félix; Rodrigues-Santos, Paulo; Ribeiro, Carlos A. Fontes3,4-Methylenedioxypyrovalerone (MDPV), a widely available synthetic cathinone, is a popular substitute for classical controlled drugs of abuse, such as methamphetamine (METH). Although MDPV poses public health risks, its neuropharmacological profile remains poorly explored. This study aimed to provide evidence on that direction. Accordingly, C57BL/6J mice were exposed to a binge MDPV or METH regimen (four intra...
Blueberry counteracts prediabetes in a hypercaloric diet-induced rat model and ...
Nunes, Sara; Viana, Sofia D.; Preguiça, Inês; Alves, André; Fernandes, Rosa; Teodoro, João S.; Matos, Patrícia; Figueirinha, Artur; Salgueiro, LígiaThe paramount importance of a healthy diet in the prevention of type 2 diabetes is now well recognized. Blueberries (BBs) have been described as attractive functional fruits for this purpose. This study aimed to elucidate the cellular and molecular mechanisms pertaining to the protective impact of blueberry juice (BJ) on prediabetes. Using a hypercaloric diet-induced prediabetic rat model, we evaluated the effe...
Is Gut Microbiota Dysbiosis a Predictor of Increased Susceptibility to Poor Out...
Ferreira, Carolina; Viana, Sofia D.; Reis, FlávioThe scientific knowledge already attained regarding the way severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects human cells and the clinical manifestations and consequences for Coronavirus Disease 2019 (COVID-19) patients, especially the most severe cases, brought gut microbiota into the discussion. It has been suggested that intestinal microflora composition plays a role in this disease becaus...
Diet-Induced Rodent Models of Diabetic Peripheral Neuropathy, Retinopathy and N...
Preguiça, Inês; Alves, André; Nunes, Sara; Gomes, Pedro; Fernandes, Rosa; Viana, Sofia D.; Reis, FlávioUnhealthy dietary habits are major modifiable risk factors for the development of type 2 diabetes mellitus, a metabolic disease with increasing prevalence and serious consequences. Microvascular complications of diabetes, namely diabetic peripheral neuropathy (DPN), retinopathy (DR), and nephropathy (DN), are associated with high morbidity rates and a heavy social and economic burden. Currently, available thera...
Crescent-Like Lesions as an Early Signature of Nephropathy in a Rat Model of Pr...
Nunes, Sara; Alves, André; Preguiça, Inês; Barbosa, Adelaide; Vieira, Pedro; Mendes, Fernando; Martins, Diana; Viana, Sofia D.; Reis, FlávioDiabetic nephropathy (DN) is a major microvascular complication of diabetes. Obesity and hyperlipidemia, fueled by unhealthy food habits, are risk factors to glomerular filtration rate (GFR) decline and DN progression. Several studies recommend that diabetic patients should be screened early (in prediabetes) for kidney disease, in order to prevent advanced stages, for whom the current interventions are clearly ...
Blueberry Consumption Challenges Hepatic Mitochondrial Bioenergetics and Elicit...
Nunes, Sara; Viana, Sofia D.; Preguiça, Inês; Alves, André; Fernandes, Rosa; Teodoro, João S.; Figueirinha, Artur; Salgueiro, Lígia; Silva, SaraAn emergent trend of blueberries' (BB) "prophylactic" consumption, due to their phytochemicals' richness and well-known health-promoting claims, is widely scaled-up. However, the benefits arising from BB indiscriminate intake remains puzzling based on incongruent preclinical and human data. To provide a more in-depth elucidation and support towards a healthier and safer consumption, we conducted a translation-m...
Blueberry consumption challenges hepatic mitochondrial bioenergetics and elicit...
Nunes, Sara; Viana, Sofia D.; Preguiça, Inês; Alves, André; Fernandes, Rosa; Teodoro, João S.; Figueirinha, Artur; Salgueiro, Lígia; Silva, SaraAn emergent trend of blueberries’ (BB) “prophylactic” consumption, due to their phytochemicals’ richness and well-known health-promoting claims, is widely scaled-up. However, the benefits arising from BB indiscriminate intake remains puzzling based on incongruent preclinical and human data. To provide a more in-depth elucidation and support towards a healthier and safer consumption, we conducted a translation-m...
Therapeutic Use of mTOR Inhibitors in Renal Diseases: Advances, Drawbacks, and ...
Viana, Sofia D.; Reis, Flávio; Alves, RuiThe mammalian (or mechanistic) target of rapamycin (mTOR) pathway has a key role in the regulation of a variety of biological processes pivotal for cellular life, aging, and death. Impaired activity of mTOR complexes (mTORC1/mTORC2), particularly mTORC1 overactivation, has been implicated in a plethora of age-related disorders, including human renal diseases. Since the discovery of rapamycin (or sirolimus), mor...