2 documents found, page 1 of 1
Downregulated glia interplay and increased miRNA-155 as promising markers to tr...
Cunha, Carolina; Santos, Catarina; Gomes, Cátia; Fernandes, Adelaide; Marcal Correia, Alexandra; Sebastião, Ana M; Vaz, Ana R; Brites, DoraAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of unknown cause. Absence of specific targets and biomarkers compromise the development of new therapeutic strategies and of innovative tools to stratify patients and assess their responses to treatment. Here, we investigate changes in neuroprotective-neuroinflammatory actions in the spinal cord of SOD1 G93A mice, at presymptomatic and sym...
The giant miniature endplate potentials frequency is increased in aged rats
Pousinha, Paula; Marcal Correia, Alexandra; Sebastião, Ana M; Ribeiro, Joaquim A.At the neuromuscular junction, spontaneous giant events (GMEPPs) are enhanced in different conditions when degenerative and/or remodeling processes take place, but no one investigated their incidence upon aging. In the present work, we evaluated evoked and spontaneous neuromuscular transmission events recorded from single muscle fibers. Phrenic-diaphragm preparations of 3-4, 12-16, 36-40 and 70-80 weeks old rat...