17 documents found, page 1 of 2
An HIV-1/HIV-2 Chimeric Envelope Glycoprotein Generates Binding and Neutralisin...
Taveira, Nuno; Figueiredo, Inês; Calado, Rita; Martin, Francisco; Bártolo, Inês; Marcelino, José Maria; Borrego, Pedro; Cardoso, Fernando M HThe development of immunogens that elicit broadly reactive neutralising antibodies (bNAbs) is the highest priority for an HIV vaccine. We have shown that a prime-boost vaccination strategy with vaccinia virus expressing the envelope glycoprotein gp120 of HIV-2 and a polypeptide comprising the envelope regions C2, V3 and C3 elicits bNAbs against HIV-2. We hypothesised that a chimeric envelope gp120 containing th...
Long-Term and Low-Level Envelope C2V3 Stimulation by Highly Diverse Virus Isola...
Martin, Francisco; Marcelino, José Maria; Palladino, Claudia; Bártolo, Inês; Tracana, Susana; Moranguinho, Inês; Gonçalves, Paloma; Mateus, RitaA minority of HIV-1-infected patients produce broadly neutralizing antibodies (bNAbs). Identification of viral and host correlates of bNAb production may help develop vaccines. We aimed to characterize the neutralizing response and viral and host-associated factors in Angola, which has one of the oldest, most dynamic, and most diverse HIV-1 epidemics in the world. Three hundred twenty-two HIV-1- infected adults...
Long-Term and Low-Level Envelope C2V3 Stimulation by Highly Diverse Virus Isola...
Martin, Francisco; Marcelino, José Maria; Palladino, Claudia; Bártolo, Inês; Tracana, Susana; Moranguinho, Inês; Gonçalves, Paloma; Mateus, RitaA minority of HIV-1-infected patients produce broadly neutralizing antibodies (bNAbs). Identification of viral and host correlates of bNAb production may help develop vaccines. We aimed to characterize the neutralizing response and viral and host-associated factors in Angola, which has one of the oldest, most dynamic, and most diverse HIV-1 epidemics in the world. Three hundred twenty-two HIV-1-infected adults ...
Long-Term and Low-Level Envelope C2V3 Stimulation by Highly Diverse Virus Isola...
Martin, Francisco; Marcelino, José Maria; Palladino, Claudia; Bártolo, Inês; Tracana, Susana; Moranguinho, Inês; Gonçalves, Paloma; Mateus, RitaA minority of HIV-1-infected patients produce broadly neutralizing antibodies (bNAbs). Identification of viral and host correlates of bNAb production may help develop vaccines. We aimed to characterize the neutralizing response and viral and host-associated factors in Angola, which has one of the oldest, most dynamic, and most diverse HIV-1 epidemics in the world. Three hundred twenty-two HIV-1-infected adults ...
Long-term and low-level envelope C2V3 stimulation by highly diverse virus isola...
Martin, Francisco; Marcelino, José Maria; Palladino, Claudia; Bártolo, Inês; Tracana, Susana; Moranguinho, Inês; Gonçalves, Paloma; Mateus, RitaA minority of HIV-1-infected patients produce broadly neutralizing antibodies (bNAbs). Identification of viral and host correlates of bNAb production may help develop vaccines. We aimed to characterize the neutralizing response and viral and host-associated factors in Angola, which has one of the oldest, most dynamic, and most diverse HIV-1 epidemics in the world. Three hundred twenty-two HIV-1-infected adults ...
Phylogeography of hepatitis B virus : the role of Portugal in the early dissemi...
Marcelino, Rute; Ezeonwumelu, Ifeanyi Jude; Janeiro, André; Mimoso, Paula; Matos, Sónia; Briz, Veronica; Pimentel, Victor; Pingarilho, MartaIn Portugal, the genetic diversity, origin of HBV and the Portuguese role in the dissemination of HBV worldwide were never investigated. In this work, we studied the epidemic history and transmission dynamics of HBV genotypes that are endemic in Portugal. HBV pol gene was sequenced from 130 patients followed in Lisbon. HBV genotype A was the most prevalent (n = 54, 41.5%), followed by D (n = 44, 33.8%), and E (...
A prime-boost immunization strategy with vaccinia virus expressing novel gp120 ...
Calado, Rita; Duarte, Joana; Borrego, Pedro; Marcelino, José Maria; Bártolo, Inês; Martin, Francisco; Figueiredo, Inês; Almeida, Silvia; Luís, GraçaDevelopment of new immunogens eliciting broadly neutralizing antibodies (bNAbs) is a main priority for the HIV-1 vaccine field. Envelope glycoproteins from non-B-non-C HIV-1clades have not been fully explored as components of a vaccine. We produced Vaccinia viruses expressing a truncated version of gp120 (gp120t) from HIV-1 clades CRF02_AG, H, J, B, and C and examined their immunogenicity in mice and rabbits. M...
A Prime-Boost Immunization Strategy with Vaccinia Virus Expressing Novel gp120 ...
Calado, Rita; Duarte, Joana; Borrego, Pedro; Marcelino, José Maria; Bártolo, Inês; Martin, Francisco; Figueiredo, Inês; Almeida, Sílvia; Graça, LuisDevelopment of new immunogens eliciting broadly neutralizing antibodies (bNAbs) is a main priority for the HIV-1 vaccine field. Envelope glycoproteins from non-B-non-C HIV-1clades have not been fully explored as components of a vaccine. We produced Vaccinia viruses expressing a truncated version of gp120 (gp120t) from HIV-1 clades CRF02_AG, H, J, B, and C and examined their immunogenicity in mice and rabbits. M...
A prime-boost immunization strategy with vaccinia virus expressing novel gp120 ...
Calado, Rita; Duarte, Joana; Borrego, Pedro; Marcelino, José Maria; Bartolo, Inês; Martin, Francisco; Figueiredo, Inês; Almeida, Silvia; Graça, LuisDevelopment of new immunogens eliciting broadly neutralizing antibodies (bNAbs) is a main priority for the HIV-1 vaccine field. Envelope glycoproteins from non-B-non-C HIV-1clades have not been fully explored as components of a vaccine. We produced Vaccinia viruses expressing a truncated version of gp120 (gp120t) from HIV-1 clades CRF02_AG, H, J, B, and C and examined their immunogenicity in mice and rabbits. M...
The contribution of Institute of Hygiene and Tropical Medicine for the knowledg...
Abecasis, Ana B.; Dias, Sónia; Marcelino, José MariaOver the past 25 years, the Institute of Hygiene and Tropical Medicine (IHMT) has contributed significantly to the knowledge of the pathogenesis of infection by the human immunodeficiency virus (HIV). The studies cover various aspects of infection such as the characterization of the evolutionary history and genetic diversity of HIV in Portugal, and in some countries of Africa; changes in HIV transmission dynami...