31 documents found, page 1 of 4
Abdominal Perfusion Pressure in Critically Ill Cirrhotic Patients: a Prospectiv...
Antunes Pereira, R; Esteves, A; Sousa Cardoso, F; Perdigoto, R; Marcelino, P; Saliba, FIn critical patients, abdominal perfusion pressure (APP) has been shown to correlate with outcome. However, data from cirrhotic patients is scarce. We aimed to characterize APP in critically ill cirrhotic patients, analyze the prevalence and risk factors of abdominal hypoperfusion (AhP) and outcomes. A prospective cohort study in a general ICU specialized in liver disease at a tertiary hospital center recruited...
Intra-Abdominal Hypertension and Abdominal Compartment Syndrome in the Critical...
Pereira, R; Buglevski, M; Perdigoto, R; Marcelino, P; Saliba, F; Blot, S; Starkopf, JBackground: Liver cirrhosis and ascites are risk factors for intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS); however, data is scarce. We aimed to determine the prevalence of IAH/ACS in a population of critically ill cirrhotic patients with acute medical illness in intensive care and to assess for risk factors and clinical outcomes. Methods: This was a multicentric retrospective coho...
Acute-on-Chronic Liver Failure: A Portuguese Single-Center Reference Review
Verdelho, M; Perdigoto, R; Machado, J; Mateus, É; Marcelino, P; Pereira, R; Fortuna, P; Bagulho, L; Bento, L; Ribeiro, F; Nolasco, F; Martins, AAcute-on-chronic liver failure (ACLF) is a syndrome characterized by an acute deterioration of a patient with cirrhosis, frequently associated with multi-organ failure and a high short-term mortality rate. We present a retrospective study that aims to characterize the presentation, evolution, and outcome of patients diagnosed with ACLF at our center over the last 3 years, with a comparative analysis between the...
Uma causa rara de insuficiência hepática aguda fulminante num jovem adulto
Alexandrino, G; Bernardo, S; Bagulho, L; Marcelino, P; Lopes, VA existência de alterações ligeiras nas provas hepáticas é uma manifestação comum do golpe de calor. Geralmente, existe uma elevação transitória e assintomática das transaminases. No entanto, formas graves de insuficiência hepática aguda (IHA) são extremamente raras neste contexto. Descreve-se um caro raro de IHA fulminante induzida por golpe de calor. Trata-se de um rapaz de 20 anos, saudável, que colapsou sub...
Acute Liver Failure: An Up-To-Date Approach
Cardoso, FS; Marcelino, P; Bagulho, L; Karvellas, CAcute liver failure is a rare but potentially devastating disease. Throughout the last few decades, acute liver failure outcomes have been improving in the context of the optimized overall management. This positive trend has been associated with the earlier recognition of this condition, the improvement of the intensive care unit management, and the developments in emergent liver transplantation. Accordingly, w...
Simultaneous Kidney-Pancreas Transplantation With an Original "Transverse Pancr...
Paulino, J; Martins, A; Vigia, E; Marcelino, P; Nobre, AM; Bicho, L; Filipe, E; Barroso, EAn innovative technique for pancreas transplantation is described. The main aspect consists of the horizontal positioning of the pancreas, which allows a better venous outflow, thus preventing thrombosis and graft loss. The program of pancreas transplantation in this national reference center for pancreatic and liver surgery was started in 2007; the initial results were considered poor, resulting in the loss of...
Mielinólise Centropôntica e Extrapôntica: Experiência de um Centro de Transplan...
Fernandes, MA; Miranda, S; Marcelino, P; Mega, I; Machado, J; Perdigoto, R; Barroso, EIntrodução: A mielinólise centropôntica e extrapôntica (MCPEP) é uma síndrome desmielinizante rara. A MCPEP é mais prevalente em receptores de transplante hepático tendo um prognóstico desfavorável associado. A correção rápida de hiponatremia e agentes imunossupressores, como os inibidores da calcineurina, foram identificados como causas possíveis para o desenvolvimento desta patologia. Métodos: Os autores desc...
Therapeutic Activity of Superoxide Dismutase-Containing Enzymosomes on Rat Live...
Marcelino, P; Marinho, HS; Campos, MC; Neves, AR; Real, C; Fontes, FS; Carvalho, A; Feio, G; Martins, MB; Corvo, MLLiver ischaemia-reperfusion injury (IRI) may occur during hepatic surgery and is unavoidable in liver transplantation. Superoxide dismutase enzymosomes (SOD-enzymosomes), liposomes where SOD is at the liposomal surface expressing enzymatic activity in intact form without the need of liposomal disruption, were developed with the aim of having a better insight into its antioxidant therapeutic outcome in IRI. We a...
Infections After Liver Transplantation: A Retrospective, Single-Center Study
Antunes, M; Teixeira, A; Fortuna, P; Moya, B; Martins, A; Bagulho, L; Pereira, JP; Bento, L; Perdigoto, R; Barroso, E; Marcelino, PObjective. To access the incidence of infectious problems after liver transplantation (LT). Design. A retrospective, single-center study. Materials and Methods. Patients undergoing LT from January 2008 to December 2011 were considered. Exclusion criterion was death occurring in the first 48 hours after LT. We determined the site of infection and the bacterial isolates and collected and compared recipient’s vari...
Clinical Outcomes and Genetic Expression Profile in Human Liver Graft Dysfuncti...
Paulino, J; Vigia, E; Marcelino, P; Abade, O; Sobral, J; Ligeiro, D; Carvalho, A; Alves, M; Papoila, AL; Trindade, H; Barroso, EIntroduction. This study aims to compare the molecular gene expression during ischemia reperfusion injury. Several surgical times were considered: in the beginning of the harvesting (T0), at the end of the cold ischemia period (T1), and after reperfusion (T2) and compared with graft dysfunction after liver transplant (OLT). Methods. We studied 54 patients undergoing OLT. Clinical, laboratory data, and histologi...