16 documents found, page 1 of 2
Enhancing Cancer Vaccine Efficacy
Gibadullin, Ruslan; Suárez, Óscar; Lazaris, Foivos S.; Gutiez, Naiara; Atondo, Estibaliz; Araujo-Aris, Sarai; Eguskiza, Ander; Niu, JianiFunding Information: This project has received partial funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 956544. This work was also supported in part by the National Institutes of Health grant (R01 GM056414 and its successor R35 GM151985) awarded to S.H.G. We thank the Agencia Estatal de Investigación (AEI, PID2021-127622OB-I00 ...
The role of sialoglycans in modulating dendritic cell function and tumour immunity
Silva, Zélia; Soares, Cátia O.; Barbosa, Mariana; Palma, Angelina S.; Marcelo, Filipa; Videira, Paula A.Funding Information: This work was also supported by the European Commission through the GLYCOTwinning project (Grant Agreement: 101079417).PAV and ZS contributed to the conception and coordination of the work. PAV, ZS, CS, MB, ASP, and FM performed the literature search and organized the data. PAV, ZS, CS, and FM wrote the original draft. All authors contributed to the writing, read, revised, and approved the ...
Decoding the Molecular Basis of the Specificity of an Anti-sTn Antibody
Soares, Cátia O.; Laugieri, Maria Elena; Grosso, Ana Sofia; Natale, Mariangela; Coelho, Helena; Behren, Sandra; Yu, Jin; Cai, Hui; Franconetti, AntonioFunding Information: This work is funded by the European Union under Horizon Europe (project 101079417 \u2500 GLYCOTwinning).The authors also thank Agencia Estatal de Investigacio\u0301n of Spain (PID2021-127662OB-I00 to F.C. and PID2019-107770RA-I00 to J.E.-O), the Juan de la Cierva Formacio\u0301n 2021 (FJC2021-046465-I to M.E.L). J.J.-B, J.E.-O, and M.E.L. also thank the Severo Ochoa Center of Excellence Acc...
The pleiotropic CLEC10A
van der Meijs, Nadia L.; Travecedo, Maria Alejandra; Marcelo, Filipa; van Vliet, Sandra J.Publisher Copyright: © 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.; Introduction: CLEC10A is a C-type lectin receptor that specifically marks the conventional dendritic cell subsets two and three (cDC2 and DC3). It has a unique recognition profile of glycan antigens, with terminal N-Acetylgalactosamine residues that are frequently present in the tumor microenvironment...
Unraveling Molecular Recognition of Glycan Ligands by Siglec-9 via NMR Spectros...
Atxabal, Unai; Nycholat, Corwin; Pröpster, Johannes M.; Fernández , Andrea; Oyenarte, Iker; Lenza, Maria Pia; Franconetti, Antonio; Soares, Cátia O.Funding Information: The Bilbao lab acknowledge the NMR resources and the technical support provided by the Euskadi NMR lab (LRE) of the ICTS “Red de Laboratorios de RMN de biomoléculas (R-LRB)” of Spain.F.M. and J.J.B. acknowledge to the European commission for the COST Action 18132 GLYCONANOPROBES. We thank Agencia Estatal de Investigación of Spain for grants PID2019-107770RA-I00 (J.E.-O.) and the Severo Ocho...
Structure-Guided Approach for the Development of MUC1-Glycopeptide-Based Cancer...
Bermejo, Iris A.; Guerreiro, Ana; Eguskiza, Ander; Martínez-Sáez, Nuria; Lazaris, Foivos S.; Asín, Alicia; Somovilla, Víctor J.; Compañón, IsmaelF.C. thanks the Mizutani Foundation for Glycoscience (grant 220115). I.A.B. and A.A. thank the Asociación Española Contra el Cancer (AECC), sección La Rioja, for doctoral fellowship. We thank the ALBA (Barcelona, Spain) synchrotron beamline XALOC. We thank ARAID, the Agencia Estatal de Investigación (AEI, BFU2016-75633-P and PID2019-105451GB-I00 to R.H.-G., PID2021-127622OB-I00 and PDC2022-133725-C21 to F.C., P...
Structural insights into Siglec-15 reveal glycosylation dependency for its inte...
Lenza, Maria Pia; Egia-Mendikute, Leire; Antoñana-Vildosola, Asier; Soares, Cátia O.; Coelho, Helena; Corzana, Francisco; Bosch, AlexandreFunding Information: X-ray diffraction experiments described in this paper were performed using beamlines XALOC synchrotron at ALBA (Spain) and PXIII in Swiss Light Source (Switzerland). The NMR spectrometers are part of the National NMR Network (PTNMR) and are partially supported by Infrastructure Project No 22161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC). F.M. and J.J.-...
Atomic and Specificity Details of Mucin 1 O-Glycosylation Process by Multiple P...
Coelho, Helena; Rivas, Matilde De Las; Grosso, Ana S.; Diniz, Ana; Soares, Cátia O.; Francisco, Rodrigo A.; Dias, Jorge S.; Compañon, IsmaelIF/00780/2015 PTDC/BIA-MIB/31028/2017 UIDP/04378/2020 UIDB/04378/2020 LA/P/0140/2020 SFRH/BD/140394/2018 PD/BD/142847/2018 PD00065/2013 DL 57/2016 ROTEIRO/0031/2013-PINFRA/22161/2016 BFU2016-75633-P PID2019-105451GB-I00 E34_R17 LMP58_18 to R.H-G RTI2018-099592-B-C21 ITN, GA-642157 COST Action GLYCONanoProbes (CA18132) ERC-2017-AdG, project number 788143-RECGLYCANMR RTI218-094751-B-C21) DNRF107; The large family...
Structural basis for the synthesis of the core 1 structure by C1GalT1
González-Ramírez, Andrés Manuel; Grosso, Ana Sofia; Yang, Zhang; Compañón, Ismael; Coelho, Helena; Narimatsu, Yoshiki; Clausen, Henrik; Marcelo, FilipaLA/P/0140/2020 MX20229-11 BFU2016-75633-P PID2019-105451GB-I00 RTI2018-099592-B-C21 E34_R17 LMP58_18 DNRF107 LA/P/0140/2020 2020.00233.CEECIND 2020.03261.CEECIND ROTEIRO/0031/2013–PINFRA/22161/2016 N°283570 BIOSTRUCTX_5186). Publisher Copyright: © 2022, The Author(s).; C1GalT1 is an essential inverting glycosyltransferase responsible for synthesizing the core 1 structure, a common precursor for mucin-type O-gly...
Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophag...
Gabba, Adele; Bogucka, Agnieszka; Luz, John G.; Diniz, Ana; Coelho, Helena; Corzana, Francisco; Cañada, Francisco Javier; Marcelo, Filipa12/IA/1398 16/IA/4419 GOIPG/2016/858 IF/00780/2015 PTDC/BIA-MIB/31028/2017 UIDB/04378/2020 PD/BD/142847/2018 RTI2018-094751-B-C22 RTI2018-099592-B-C2.; The human macrophage galactose lectin (MGL) is an endocytic type II transmembrane receptor expressed on immature monocyte-derived dendritic cells and activated macrophages and plays a role in modulating the immune system in response to infections and cancer. MGL...