8 documents found, page 1 of 1
Gender-related differences in cardiometabolic risk factors and oxidative stress...
Godinho, N; Morato, M; Albino-Teixeira, A; Afonso, AC; Sousa, T; Correia-Costa, L"Objectives Gender-related differences in oxidative stress, nitric oxide bioavailability, and cardiometabolic risk factors were examined in a cross-sectional study involving 313 prepubertal children (8–9 years old) from the generation XXI birth-cohort. Methods Anthropometric measurements, cardiometabolic variables, and redox markers were assessed, including plasma and urinary isoprostanes (P-Isop, U-Isop), plas...
Association between blood pressure and angiotensin-converting enzymes activity ...
Gaspar, AR; Andrade, B; Mosca, S; Ferreira-Duarte, M; Teixeira, A; Cosme, D; Albino-Teixeira, A; Ronchi, FA; Leite, AP; Casarini, DE; Areias, JCObjectives:Angiotensin-converting enzymes' (ACEs) relationship with blood pressure (BP) during childhood has not been clearly established. We aimed to compare ACE and ACE2 activities between BMI groups in a sample of prepubertal children, and to characterize the association between these enzymes' activities and BP.Methods:Cross-sectional study of 313 children aged 8-9 years old, included in the birth cohort Gen...
Hydrocinnamic Acid and Perillyl Alcohol Potentiate the Action of Antibiotics ag...
Sousa, M; Afonso, AC; Teixeira, LS; Anabela Borges; Saavedra, MJ; Simões, LC; Simões, M; Simões MThe treatment of bacterial infections has been troubled by the increased resistance to antibiotics, instigating the search for new antimicrobial therapies. Phytochemicals have demonstrated broad-spectrum and effective antibacterial effects as well as antibiotic resistance-modifying activity. In this study, perillyl alcohol and hydrocinnamic acid were characterized for their antimicrobial action against Escheric...
Gender differences in the effect of adiposity on markers of cardiovascular risk...
Leal, DA; Correia-Costa, L; Moura, C; Mota, C; Correia-Costa, A; Areias, JC; Guerra, A; Afonso, AC; Azevedo, AINTRODUCTION: In the last years, evidence has started to emerge on the presence of cardiometabolic differences between genders before puberty. This study aims to evaluate if the association between obesity and markers of cardiovascular risk is different between genders in 8 to 9-year-olds. METHODS: Cross sectional study of 315 children (167 boys) aged 8-9 years old, followed in the birth cohort Generation XXI (...
Prenatal alcohol exposure affects renal function in overweight schoolchildren: ...
Correia-Costa, L; Schaefer, F; Afonso, AC; Correia, S; Guimarães, JT; Guerra, A; Barros, H; Azevedo, ABackground: Prenatal ethanol exposure has been shown to reduce nephron endowment in animal models, but the effect of alcohol during human pregnancy on postnatal kidney function has not been explored. We aim to investigate the potential association of maternal alcohol consumption during pregnancy with the offspring renal function, considering potential confounding by intrauterine growth and children’s current nu...
The Montreal Cognitive Assessment (MoCA) as a screening test for cognitive dysf...
Freitas, S; Batista, SJ; Afonso, AC; Simões, MR; de Sousa, L; Cunha, L; Santana, IThis study investigates the utility of the Portuguese version of Montreal Cognitive Assessment (MoCA) as a screening-method for identifying cognitive dysfunction (CD) in multiple sclerosis (MS). The 118 participants with comprehensive neuropsychological assessment were divided into two subgroups: (I) MS group (n = 59) and (II) control group (n = 59). The MS patients were classified as cognitively intact (n = 26...
Longer duration of obesity is associated with a reduction in urinary angiotensi...
Morato, M; Correia-Costa, L; Sousa, T; Cosme, D; Schaefer, F; Areias, JC; Guerra, A; Afonso, AC; Barros, H; Azevedo, A; Albino-Teixeira, ABackground: We aimed to study the impact of obesity on urinary excretion of angiotensinogen (U-AGT) in prepubertal children, focusing on the duration of obesity and gender. Also, we aimed to evaluate whether plasma angiotensinogen (P-AGT) and hydrogen peroxide (H2O2) play a role in the putative association. Methods: Cross-sectional evaluation of 305 children aged 8–9 years (160 normal weight, 86 overweight, and...
Association of myeloperoxidase levels with cardiometabolic factors and renal fu...
Costa, L; Sousa, T; Morato, M; Cosme, D; Afonso, J; Moura, C; Mota, C; Areias, JC; Guerra, A; Schaefer, F; Afonso, AC; Barros, H; Albino-Teixeira, AINTRODUCTION: Myeloperoxidase (MPO), an enzyme linking obesity and cardiovascular (CV) risk in adults, has rarely been studied in young children and no studies assessed its association with renal function. We sought to explore a possible association between serum MPO levels, obesity, CV risk factors and renal function in prepubertal children. MATERIALS/METHODS: Cross-sectional evaluation of 309 children aged 8-...